Effects of Supraphysiological Doses of Sex Steroids on Wheel Running Activity in Mice
| Autor: | Amy M. Knab, Alicia T. Hamilton, Trudy Moore-Harrison, Jennifer R. McCall, Robert S. Bowen, J. Timothy Lightfoot |
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| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Physical activity business.industry medicine.medical_treatment Free access Article Steroid 17β-Estradiol 03 medical and health sciences Endogenous steroids 0302 clinical medicine Endocrinology Internal medicine Wheel running medicine Sex hormones Testosterone Activity regulation Testosterone replacement business 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Journal of steroids & hormonal science |
| ISSN: | 2157-7536 |
| DOI: | 10.4172/2157-7536.1000110 |
| Popis: | The regulatory mechanisms of physical activity are postulated to include environmental and biological/genetic factors. In particular, the sex steroids appear to have profound effects on wheel running in rodents. The purpose of this project was to investigate the effects of 17β-estradiol and testosterone on wheel running distance, duration, and speed in male and female C57BL/6J mice. The mice (N=46) were provided free access to running wheels interfaced with computers to track daily running distance, duration, and speed. Activity was assessed at baseline in intact mice, after surgical gonadectomy, and after replacement with either 17β- estradiol or testosterone. Upon removal of the gonads, physical activity levels were significantly reduced in both males and females. Distance (10-30% of baseline) and duration (20-47% of baseline) measures were most affected by the loss of endogenous steroids, while running speed (60-77% of baseline) though significantly reduced-decreased by a much lower magnitude. Testosterone replacement fully recovered running distance, duration, and speed to pre-surgical levels in both sexes (100% of baseline). Distance (30-42% of baseline) and duration (43- 47% of baseline) were partially recovered by 17β-estradiol, but not to baseline levels. Speed (100% of baseline) was fully recovered by 17β-estradiol replacement in males and females. This study suggests that physical activity in mice is affected by endogenous steroids and can be altered by exogenous steroid replacement. The differences in the recovery abilities of 17β-estradiol and testosterone suggest that both estrogenic and androgenic pathways may be involved to variable degrees in activity regulation. |
| Databáze: | OpenAIRE |
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