Immunoexpression of NF-ĸB and their inhibitory subunits IĸBα and IĸBβ in giant cell lesions of the jaws: implications for their clinical behavior
| Autor: | Diana M. Isaza-Guzmán, Paulina Hurtado-García, Oscar Darío García-Quintero, Gloria Amparo Flórez-Moreno, Sergio Iván Tobón-Arroyave |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Stromal cell Adolescent Histogenesis Biology Logistic regression Inhibitory postsynaptic potential Giant Cells Pathology and Forensic Medicine Young Adult Granuloma Giant Cell medicine Humans Child Aged Retrospective Studies Univariate analysis Confounding NF-kappa B Middle Aged Immunohistochemistry Otorhinolaryngology Giant cell Child Preschool Periodontics Female Stromal Cells Oral Surgery Jaw Diseases Follow-Up Studies |
| Zdroj: | Journal of Oral Pathology & Medicine. 44:752-760 |
| ISSN: | 0904-2512 |
| DOI: | 10.1111/jop.12289 |
| Popis: | Background The unpredictable behavior of giant cell lesions (GCLs) of the jaws parallels its controversial histogenesis. This study evaluated a possible association between the immunohistochemical expression of NF-ĸB, the inhibitory subunits IĸBα/IĸBβ, and clinicopathological variables with the behavior of central and peripheral GCLs of the jaws. Materials and Methods Paraffin-embedded samples of GCLs of the jaws (n = 68) were prepared for histological/immunohistochemical assessment. Demographic and clinicopathological parameters were assessed to determine the behavior of the lesions. A staining–intensity–distribution (SID) score was used to assess the immunomarkers reactivity. The association between significant candidate immunohistochemical predictor variables regarding clinical behavior was analyzed individually and adjusted for confounding using a binary logistic regression model. Results While univariate analysis revealed a positive association of NF-ĸB SID score, NF-ĸB nuclear expression, IĸBα SID score, and NF-ĸB to inhibitors average ratio with the aggressive status of GCLs, after bivariate logistic regression analysis, only NF-ĸB nuclear expression, IĸBα SID score, and NF-ĸB to inhibitors average ratio remained as robust predictors of aggressiveness. Confounding and interaction effects regarding clinicopathological candidate predictor variables were also noted. Conclusion It looks that clinical behavior of GCLs of the jaws may be strong/independently linked to the increased nuclear expression of NF-ĸB, higher NF-ĸB to inhibitors average ratio, and decreased IĸBα SID score. Notwithstanding, there are simultaneously synergistic and opposing interactive effects with respect to age stratum, growth rate, multinucleated giant cells count, and mononuclear stromal cells density in the susceptible host that may increase the tissue destruction observed in aggressive GCLs. |
| Databáze: | OpenAIRE |
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