Beta 1 integrins in third trimester human placentae: no differential expression in pathological pregnancy
| Autor: | Richard J. Lilford, M.J. Divers, Judith N. Bulmer, David Miller |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Integrins Basal plate (neural tube) Placenta Pregnancy Trimester Third Integrin Extraembryonic Membranes Ligands Extracellular matrix Fetal membrane Pregnancy Reference Values Internal medicine medicine Humans reproductive and urinary physiology biology Integrin beta1 Decidua Obstetrics and Gynecology Trophoblast Phenotype Cell biology Extracellular Matrix Pregnancy Complications medicine.anatomical_structure Endocrinology Reproductive Medicine embryonic structures biology.protein Female Developmental Biology |
| Zdroj: | Placenta. 16(3) |
| ISSN: | 0143-4004 |
| Popis: | Integrins are a group of cell surface receptors that play important roles in cell-cell and cell-extracellular matrix interactions. The expression of trophoblast cell surface integrin subunits changes during placental development in normal pregnancy but the functional significance is unknown. The aim of this study was to investigate the expression of beta 1 integrins and their extracellular matrix ligands in human placenta and membranes in normal and pathological pregnancy using an avidin-biotin-peroxidase technique. Expression of the beta 1 integrins was similar in all study groups. Whilst there was some heterogeneity of expression of specific integrin alpha chains this was not characteristic of defined subject groups, variations occurring within all groups. Two distinct trophoblast subpopulations were demonstrated in the chorion laeve according to differential expression of beta 1 integrins. Trophoblast immediately adjacent to maternal decidua, which expressed alpha 1 rather than alpha 2, also comprised the majority of trophoblast in the basal plate; possession of the alpha 1, alpha 3, alpha 5, alpha 6 rather than alpha 2, alpha 3, alpha 5, alpha 6 phenotype may be important in the invasive potential of trophoblast populations. The results obtained in the present study indicate that the integrin phenotypes of third trimester uteroplacental tissues are similar in normal and pathological pregnancy, including pre-eclampsia, before and after labour. |
| Databáze: | OpenAIRE |
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