Relationship between Proliferative Diabetic Retinopathy and Inflammatory Markers in Patients with Type 1 Diabetes in Brazil: A Nested Case Control Study
| Autor: | Luiza Harcar Muniz, Franz Schubert Lopes Leal, Paulo Henrique Morales, Bianca Senger Vasconcelos Barros, Marília B. Gomes, Karla Rezende Guerra Drummond, André Araújo Pinheiro, Deborah Conte Santos, Felipe Mallmann, Marcela Haas Pizarro, Laura Gomes Nunes Melo, Fernando Korn Malerbi |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Renal function 01 natural sciences Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Internal medicine Humans Medicine 0101 mathematics Type 1 diabetes Diabetic Retinopathy business.industry 010102 general mathematics Case-control study General Medicine Diabetic retinopathy medicine.disease Sensory Systems Pathophysiology Ophthalmology Cross-Sectional Studies Diabetes Mellitus Type 1 chemistry Case-Control Studies Nested case-control study 030221 ophthalmology & optometry Glycated hemoglobin business Biomarkers Brazil |
| Zdroj: | Ophthalmologica. 243:471-478 |
| ISSN: | 1423-0267 0030-3755 |
| Popis: | Introduction: This study examined the relationship between proliferative diabetic retinopathy (PDR) and serum levels of C-reactive protein, VEGF, TNF-α, and IL-6 inflammatory biomarkers, related to the pathophysiology of diabetic retinopathy. Methods: This cross-sectional, case control study comprised 240 patients with type 1 diabetes (80 cases with PDR and 160 controls without diabetic retinopathy) who were matched for gender and duration of diabetes. Results: C-reactive protein was the only inflammatory biomarker that was positively related to PDR (OR 1.96; 95% CI 1.01–3.78, p = 0.0045). We also noted an association between high glycated hemoglobin levels, the use of angiotensin-converting enzyme inhibitor, low glomerular filtration rate, and PDR. Conclusion: Patients with higher levels of C-reactive protein are more likely to present with PDR. We did not find a link between serum levels of VEGF, TNF-α, or IL-6 and PDR. The function of inflammatory biomarkers in PDR must be addressed in further studies. |
| Databáze: | OpenAIRE |
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