Menopause as a predictor of new-onset asthma : A longitudinal Northern European population study
| Autor: | Thorarinn Gislason, Bryndis Benediktsdottir, Eirunn Waatevik Saure, Vivi Schlünssen, Torben Sigsgaard, Ersilia Bifulco, Ernst Omenaas, Deborah Jarvis, Mathias Holm, Luca Puggini, Ferenc Macsali, Francisco Rodríguez, Karl A. Franklin, Bénédicte Leynaert, Andrei Malinovschi, Cecilie Svanes, Trude Duelien Skorge, Gunilla Wieslander, Randi Jacobsen Bertelsen, Dan Norbäck, Julia Dratva, Elisabeth Zemp, Steinar Hustad, Francisco Gómez Real, Kai Triebner, Eva Lindberg, Shyamali C. Dharmage, Ane Johannessen |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Aging
Allergy SYMPTOMS Respiratory Medicine and Allergy menopause 0302 clinical medicine menopausal asthma immune system diseases Odds Ratio Respiratory Health in Northern Europe Medicine Immunology and Allergy Longitudinal Studies 030212 general & internal medicine Prospective cohort study Amenorrhea Lungmedicin och allergi Estradiol Incidence (epidemiology) respiratory symptoms WOMEN Middle Aged Europe Menopause LUNG-FUNCTION ESTROGEN 1107 Immunology HYSTERECTOMY Female medicine.symptom Life Sciences & Biomedicine estrogens medicine.medical_specialty longitudinal Immunology QUESTIONNAIRE FEMALE SEX-HORMONES Reproduktionsmedicin och gynekologi sex hormones 03 medical and health sciences INFLAMMATION Obstetrics Gynecology and Reproductive Medicine Humans Aged Asthma Science & Technology business.industry Odds ratio asthma medicine.disease respiratory tract diseases 030228 respiratory system PROSPECTIVE COHORT reproductive aging Physical therapy RESPIRATORY HEALTH business Body mass index Demography |
| Zdroj: | Triebner, K, Johannessen, A, Puggini, L, Benediktsdóttir, B, Bertelsen, R J, Bifulco, E, Dharmage, S C, Dratva, J, Franklin, K A, Gíslason, T, Holm, M, Jarvis, D, Leynaert, B, Lindberg, E, Malinovschi, A, Macsali, F, Norbäck, D, Omenaas, E R, Rodríguez, F J, Saure, E, Schlünssen, V, Sigsgaard, T, Skorge, T D, Wieslander, G, Zemp, E, Svanes, C, Hustad, S & Gómez Real, F 2016, ' Menopause as a predictor of new-onset asthma : A longitudinal Northern European population study ', The Journal of allergy and clinical immunology, vol. 137, no. 1, pp. 50-57.e6 . https://doi.org/10.1016/j.jaci.2015.08.019 57.e6 |
| DOI: | 10.1016/j.jaci.2015.08.019 |
| Popis: | Background: There is limited and conflicting evidence on the effect of menopause on asthma. Objectives: We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years. Methods: The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n = 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center. Results: The odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI, 1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers. Conclusions: New-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging. |
| Databáze: | OpenAIRE |
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