Diagnostic and prognostic values of endothelial-cell-specific molecule-1 with malignant pleural effusions in patients with non-small cell lung cancer
| Autor: | Yu Zhang, Guo-Jun Lu, Weiping Xie, Yongyue Wei, Chengjie Shao, Hui Kong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Pathology Lung Neoplasms Pleural effusion Biopsy Gene Expression Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Carcinoma Non-Small-Cell Lung medicine Biomarkers Tumor Malignant pleural effusion Humans Lung cancer Survival analysis non-small cell lung cancer Receiver operating characteristic business.industry Proportional hazards model Retrospective cohort study overall survival (OS) Middle Aged medicine.disease Prognosis respiratory tract diseases Neoplasm Proteins Pleural Effusion Malignant 030104 developmental biology ROC Curve 030220 oncology & carcinogenesis biomarker Female Proteoglycans ESM-1 business Biomarkers Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Guo-Jun Lu 1, 2 , Cheng-Jie Shao 1 , Yu Zhang 2 , Yong-Yue Wei 3 , Wei-Ping Xie 1 and Hui Kong 1 1 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 2 Department of Respiratory Medicine, Nanjing Chest Hospital, School of Medicine, Southeast University, Nanjing 210029, China 3 Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China Correspondence to: Wei-Ping Xie, email: wpxie@njmu.edu.cn Hui Kong, email: konghui@njmu.edu.cn Keywords: ESM-1, non-small cell lung cancer, overall survival (OS), prognosis, biomarker Received: March 22, 2017 Accepted: April 12, 2017 Published: April 27, 2017 ABSTRACT Over-expressed endothelial-cell-specific molecule-1 (ESM-1) in tumor vascular endothelium contributes to tumor angiogenesis, metastasis, and poor prognosis. However, the content of ESM-1 in pleural effusion is unclear. A retrospective study was carried out to investigate the diagnostic and prognostic values of ESM-1 with malignant pleural effusions in patients with non-small cell lung cancer (NSCLC). ESM-1 levels in malignant pleural effusion (MPE) from 70 patients with NSCLC and 50 cases of benign pleural effusion (BPE) were measured using enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) curve was calculated to assess the diagnostic value of ESM-1. Survival curves were performed by Kaplan-Meier method and survival characteristics were compared by log-rank test. Univariable and multivariate Cox proportional hazards model were carried out to analysis the significance of different prognostic factors for overall survival (OS). ESM-1 levels were significantly higher in MPE than those in BPE ( p < 0.001). By ROC curve analysis, with a cutoff level of 19.58 ng/ml, the accuracy, sensitivity, and specificity for ESM-1 diagnosis MPE were 82.5%, 81.4%, and 84.0%, respectively. Moreover, NSCLC patients with pleural fluid ESM-1 levels below 19.58 ng/ml had significant longer OS than those patients with higher levels (22.09 months vs. 11.49 months, p = 0.003). Multivariate survival analysis showed that high MPE ESM-1 level was an independent prognostic factor (HR, 1.007; p = 0.039) for the OS of NSCLC patients. This study showed that ESM-1 level in pleural effusion could be a potential diagnostic and prognostic marker in NSCLC patients with MPE. |
| Databáze: | OpenAIRE |
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