Snail modulates the assembly of fibronectin via α5 integrin for myocardial migration in zebrafish embryos
| Autor: | Hong Xu, Chun Xiao, Wentong Meng, Hongwei Gao, Ting Zhang, Lulu Jing, Hongyan Zhu, Yue Xiao, Ning Luo, Xianming Mo, Liangjun Qiao |
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| Rok vydání: | 2014 |
| Předmět: |
Embryo
Nonmammalian animal structures Morphogenesis Embryonic Development Integrin alpha5 Snail Biology Article Cell Movement biology.animal parasitic diseases Animals Heart formation Zebrafish Gene knockdown Multidisciplinary Heart development Myocardium fungi Embryogenesis Heart Zebrafish Proteins biology.organism_classification Molecular biology Fibronectins Fibronectin biology.protein Snail Family Transcription Factors Transcription Factors |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep04470 |
| Popis: | The Snail family member snail encodes a zinc finger-containing transcriptional factor that is involved in heart formation. Yet, little is known about how Snail regulates heart development. Here, we identified that one of the duplicated snail genes, snai1b, was expressed in the heart region of zebrafish embryos. Depletion of Snai1b function dramatically reduced expression of α5 integrin, disrupted Fibronectin layer in the heart region, especially at the midline, and prevented migration of cardiac precursors, resulting in defects in cardiac morphology and function in zebrafish embryos. Injection of α5β1 protein rescued the Fibronectin layer and then the myocardial precursor migration in snai1b knockdown embryos. The results provide the molecular mechanism how Snail controls the morphogenesis of heart during embryonic development. |
| Databáze: | OpenAIRE |
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