Ten years after acquiring an HIV-1 infection: a study in a cohort of eleven neonates infected by aliquots from a single plasma donation
| Autor: | H. Van Den Berg, J. M. J. J. Vossen, L. J. Dooren, M.J.D. van Tol, E. J. A. Gerritsen |
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| Rok vydání: | 1994 |
| Předmět: |
Pediatrics
medicine.medical_specialty Cellular immunity Immunoglobulins Blood Donors HIV Infections Asymptomatic Acquired immunodeficiency syndrome (AIDS) Blood plasma medicine Humans Child Immunity Cellular biology business.industry Infant Newborn Transfusion Reaction Gestational age General Medicine Prognosis medicine.disease Pediatrics Perinatology and Child Health Cohort Immunology HIV-1 biology.protein Viral disease medicine.symptom Antibody business Follow-Up Studies |
| Zdroj: | Acta Paediatrica. 83:173-178 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1994.tb13045.x |
| Popis: | We present data from a 10-year follow-up study of 11 children who had been infected in the neonatal period by small aliquots of plasma from a single donation. Three of the children died within the first 2.5 years of life, 5 other children died between 6.2 and 11 years after infection and 3 are alive at present. The latter children are classified as P1B (asymptomatic), P2A (non-specific findings) and P2B (neurological changes). All infected children showed progressive decline of cellular immunity. Immunoglobulin levels in serum were increased in the majority of children for prolonged periods and homogeneous immunoglobulin components were present. The severity of the disease was related neither to the clinical condition of the infants in the neonatal period nor to the volume of transfused plasma, the interval between freezing and thawing of the plasma, gestational age at birth and age at transfusion. Coinciding infections with other viruses had no impact on disease progression during the follow-up period of 10 years. |
| Databáze: | OpenAIRE |
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