Pseudomonas aeruginosa infective endocarditis in patients who do not use intravenous drugs: Analysis of risk factors and treatment outcomes
| Autor: | Yao-Shen Chen, Kai-Sheng Hsieh, Ying-Yao Chen, Yu-Shen Chen, Chin-An Chou, Yung-Feng Huang, Ting-I Lin, Po-Yen Liu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Prosthesis-Related Infections Disease 030204 cardiovascular system & hematology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Risk Factors Immunology and Microbiology(all) Internal medicine medicine Immunology and Allergy Endocarditis Infection control Humans 030212 general & internal medicine Hospital Mortality Native Valve Endocarditis Univariate analysis General Immunology and Microbiology infective endocarditis Pseudomonas aeruginosa business.industry Mortality rate General Medicine Endocarditis Bacterial Middle Aged medicine.disease Surgery Infectious Diseases Treatment Outcome Infective endocarditis business |
| Zdroj: | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 49(4) |
| ISSN: | 1995-9133 |
| Popis: | Background Infective endocarditis (IE) due to Pseudomonas aeruginosa is rare and accounts for only about 3% of all patients with this disease. Most infections are associated with the use of intravenous drugs. Patients with P. aeruginosa -related IE who do not use intravenous drugs are extremely rare. We carried out a review of the literature to identify the nature and risk factors of this disease. Methods Patients with IE reported between 1993 and 2013 were reviewed by searching the Medline database using the keywords "endocarditis" and " Pseudomonas aeruginosa ". All of the patients included met the definition of the modified Duke criteria. Results Twenty-seven patients in 22 reports were reviewed. IE associated with health care accounted for 20 patients (74%). The mean age of the patients was 53.4 years and there was a predominance of men (81.5%). Native valve endocarditis was seen in 20 (74.1%) patients. Surgery for infection control was performed in 15 (55.6%) patients and the mortality rate in patients who underwent surgery was 33.3% (five patients). A relapse of IE after adequate treatment was seen in nine (33.3%) patients. The mortality rate in all 27 patients was 28.6% (2/7) for those with community-acquired IE and 40% (8/20) for those with IE associated with health care. Univariate analysis showed a higher mortality rate in patients aged >60 years and in those whose source of endocarditis was related to a prosthetic device. Conclusion P. aeruginosa endocarditis has substantial morbidity and mortality. It is characterized by easy relapse and is highly associated with prosthetic devices. |
| Databáze: | OpenAIRE |
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