Metabolism and disposition of 2,2′,4,4′,5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice

Autor:	Leo T. Burka, E. H. Lebetkin, L.-J. Chen, J. M. Sanders
Rok vydání:	2006
Předmět:	Male medicine.medical_specialty Health Toxicology and Mutagenesis F344 rats Administration Oral Adipose tissue Ether Urine Toxicology Biochemistry Mice chemistry.chemical_compound Sex Factors Species Specificity Internal medicine Halogenated Diphenyl Ethers medicine Animals Feces Pharmacology Carbon Isotopes Dose-Response Relationship Drug Chemistry Phenyl Ethers General Medicine Metabolism Rats Inbred F344 Pentabromodiphenyl ether Rats Endocrinology Adipose Tissue Female Glucuronide Oxidation-Reduction
Zdroj:	Xenobiotica. 36:515-534
ISSN:	1366-5928 0049-8254
DOI:	10.1080/00498250600674477
Popis:	The metabolism and disposition of 14C-labelled 2,2',4,4',5-pentabromodiphenyl ether (BDE99) were studied in F344 rats and B6C3F1 mice. Approximately 85% of a 1 micromol kg-1 oral dose was absorbed by male rats and mice. Within 24 h following oral doses ranging from 0.1 to 1000 micromol kg-1 to rats, 39-47% of the dose was excreted in the faeces (including 16% unabsorbed), up to 2% was excreted in the urine, and 34-38% remained in the tissues, mostly in adipose tissue. Mice excreted more in the urine and less in the faeces than rats. Tissue accumulation was observed following repeated dosing to rats. Two dihydrohydroxy-S-glutathionyl and two S-glutathionyl conjugates of BDE99, 2,4,5-tribromophenol glucuronide, two mono-hydroxylated BDE99 glucuronides, and three mono-hydroxylated tetrabromodiphenyl ether glucuronides were identified in male rat bile. 2,4,5-Tribromophenol and its glucuronide and sulfate conjugates, were identified in male rat urine. 2,4,5-Tribromophenol, one mono-hydroxylated tetrabromodiphenyl ether, and two mono-hydroxylated BDE99 were characterized in male rat faeces. BDE99 undergoes more extensive metabolism than does BDE47. Half of the absorbed oral dose in male rats was excreted in 10 days mostly as metabolites derived from arene oxide intermediates.
Databáze:	OpenAIRE
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