A model of viral wheeze in nonasthmatic adults: symptoms and physiology
| Autor: | Michael Silverman, M Leech, C. Hewitt, Paul C. Lambert, S Myint, M C Mckean |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Rhinitis Allergic Perennial Physiology Common Cold Bronchial Provocation Tests Atopy Airway resistance Risk Factors Wheeze medicine Humans Respiratory sounds Respiratory Tract Infections Asthma Respiratory Sounds Respiratory tract infections medicine.diagnostic_test business.industry Airway Resistance Common cold Intradermal Tests medicine.disease Immunology Female Viral disease medicine.symptom business Coronavirus Infections |
| Zdroj: | The European respiratory journal. 18(1) |
| ISSN: | 0903-1936 |
| Popis: | Episodic wheezing associated with viral infections of the upper respiratory tract (URT) is a common problem in young children but also occurs in adults. It is hypothesized that an experimental infection with human coronavirus (HCoV), the second most prevalent common cold virus, would cause lower respiratory tract (LRT) changes in adults with a history of viral wheeze.Twenty-four viral wheezers (15 atopic) and 19 controls (seven atopic) were inoculated with HCoV 229E and monitored for the development of symptoms, changes in airway physiology and provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (FEV1) (PC20). At baseline, viral wheezers were similar to controls in PC20(mean±sd log2PC20: 5.1±1.9 and 5.8±1.4 g·L−1, respectively) but had a lower FEV1than controls (mean±sd 85.8±11.4 and 95.6±13.2% predicted, respectively p1and peak expiratory flow on days with LRT symptoms (days 3–6), but a progressive reduction in PC20from baseline on days 2, 4 and 17 after inoculation (by 0.82, 1.35 and 1.82 doubling concentrations, respectively). The fall in PC20affected both atopic and nonatopic subjects equally. There were no changes in FEV1or PC20in controls.An adult model of viral wheeze that is independent of atopy and therefore, of classical atopic asthma was established. |
| Databáze: | OpenAIRE |
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