Cardiovascular Outcomes and All-Cause Mortality in Patients with Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease (Overlap Syndrome)
| Autor: | Jacqueline S. Sandoz, Tetyana Kendzerska, Shawn D. Aaron, Andrea S. Gershon, Richard S. Leung, Najib T. Ayas |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Pulmonary disease Kaplan-Meier Estimate urologic and male genital diseases Severity of Illness Index Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Humans Medicine In patient Prospective Studies 030212 general & internal medicine Mortality Hypoxia Aged Proportional Hazards Models Ontario Sleep Apnea Obstructive COPD business.industry Incidence Overlap syndrome Syndrome Middle Aged medicine.disease respiratory tract diseases Hospitalization Obstructive sleep apnea 030228 respiratory system Cardiovascular Diseases Sleep apnea syndromes Cardiology Female business Cardiovascular outcomes All cause mortality |
| Zdroj: | Annals of the American Thoracic Society. 16:71-81 |
| ISSN: | 2325-6621 2329-6933 |
| DOI: | 10.1513/annalsats.201802-136oc |
| Popis: | The combined impact of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) on cardiovascular outcomes remains controversial.We determined whether the combined presence of COPD and severe OSA defined by the apnea-hypopnea index (AHI) or degree of nocturnal hypoxemia is associated with increased hazards of cardiovascular events and mortality.Prospectively collected data from adults with suspected OSA who underwent sleep study between 1994 and 2010 were linked to provincial administrative data to determine a presence of COPD and composite outcome. Exposures of interest were: 1) AHI greater than 30, and 2) 10 or more minutes of sleep time spent with oxygen saturation (SaAmong 10,149 participants, 30% had AHI greater than 30, 25% spent at least 10 minutes of sleep with SaIn adults with suspected OSA, the co-occurrence of nocturnal hypoxemia and COPD was associated with an increased hazard of cardiovascular events and mortality with a synergistic effect found only in women. |
| Databáze: | OpenAIRE |
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