Non-steroidal Anti-inflammatory Drugs as Candidates for the Prevention or Treatment of Alzheimer’s Disease: Do they Still Have a Role?
| Autor: | Julián Benito-León, Alberto Villarejo-Galende, Sara Llamas-Velasco, Víctor A. Blanco-Palmero, Marta González-Sánchez |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Population Disease Bioinformatics 03 medical and health sciences 0302 clinical medicine Immune system Alzheimer Disease Epidemiology medicine Humans education Therapeutic strategy Inflammation Clinical Trials as Topic education.field_of_study business.industry Anti-Inflammatory Agents Non-Steroidal Brain Clinical trial 030104 developmental biology Neurology Non steroidal anti inflammatory Neurology (clinical) business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Current Alzheimer Research. 17:1013-1022 |
| ISSN: | 1567-2050 |
| Popis: | Purpose of Review: To provide an updated analysis of the possible use of non-steroidal anti-inflammatory drugs (NSAIDs) as treatments for Alzheimer´s disease (AD). Recent Findings: Neuroinflammation in AD is an active field of research, with increasing evidence from basic and clinical studies for an involvement of innate or adaptive immune responses in the pathophysiology of AD. Few clinical trials with anti-inflammatory drugs have been performed in the last decade, with negative results. Summary: Besides the information gathered from basic research, epidemiological studies have provided conflicting findings, with most case-control or prevalence studies suggesting an inverse relationship between NSAIDs use and AD, but divided results in prospective population-based incident cohort studies. Clinical trials with different NSAIDs are almost unanimous in reporting an absence of clear benefit in AD. Conclusion: The modulation of inflammatory responses is a promising therapeutic strategy in AD. After three decades of research, it seems that conventional NSAIDs are not the best pharmacological option, both for their lack of clear effects and for an unfavorable side-effect profile in long-term treatment. The development of other anti-inflammatory drugs as candidate treatments in AD may benefit from the knowledge acquired with NSAIDs. |
| Databáze: | OpenAIRE |
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