Incidence and risk factors for life-threatening bleeding after allogeneic stem cell transplant
| Autor: | María Consuelo del Cañizo, Fermín Sánchez-Guijo, Lourdes Vázquez, Carmen Guerrero, Jorge Labrador, Francisco Lozano, Lucía López-Corral, José Ramón González-Porras, Ignacio Alberca, Dolores Caballero, Mercedes Sánchez-Barba |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Gastrointestinal bleeding medicine.medical_specialty Transplantation Conditioning Thrombotic microangiopathy Graft vs Host Disease Hemorrhage Disease Risk Factors immune system diseases hemic and lymphatic diseases medicine Humans Transplantation Homologous Aged business.industry Incidence Incidence (epidemiology) Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease Surgery Patient Outcome Assessment Transplantation surgical procedures operative Graft-versus-host disease Female Stem cell Complication business |
| Zdroj: | British Journal of Haematology. 169:719-725 |
| ISSN: | 0007-1048 |
| Popis: | Summary Bleeding is a frequent complication after allogeneic haematopoietic stem cell transplantation (HSCT) and may affect survival. The purpose of this study was to determine the incidence and risk factors for life-threatening bleeding after HSCT by retrospective evaluation of 491 allogeneic HSCT recipients. With a median follow-up of 33 months, 126 out of 491 allogeneic HSCT recipients experienced a haemorrhagic event (25·7%) and 46 patients developed a life-threatening bleeding episode (9·4%). Pulmonary and gastrointestinal bleeding were the most common sites for life-threatening bleeding, followed by central nervous system. In multivariate analyses, the presence of severe thrombocytopenia after day +28 and the development of grade III–IV acute graft-versus-host disease (GVHD) or thrombotic microangiopathy (TMA) retained their association with life-threatening bleeding events. The overall survival at 3 years among patients without bleeding was 67·1% for only 17·1% for patients with life-threatening bleeding (P |
| Databáze: | OpenAIRE |
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