The Mormyrid Electrosensory LobeIn Vitro: Physiology and Pharmacology of Cells and Circuits
| Autor: | Kirsty Grant, Victor Z. Han, Leonel Gómez, Curtis C. Bell, Yoshiko Sugawara |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Physiology
Stimulation AMPA receptor In Vitro Techniques Biology Pharmacology Inhibitory postsynaptic potential Synaptic Transmission Article Membrane Potentials Purkinje Cells Nerve Fibers Ganglia Sensory Animals Glycine receptor Electric Organ GABAA receptor musculoskeletal neural and ocular physiology General Neuroscience Glutamate receptor Excitatory Postsynaptic Potentials Neural Inhibition Electric Stimulation nervous system Excitatory postsynaptic potential NMDA receptor Neuroscience Electric Fish |
| Zdroj: | The Journal of Neuroscience. 18:6009-6025 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.18-15-06009.1998 |
| Popis: | This paper is concerned with the electrosensory lobe (ELL) of mormyrid electric fish as examined inin vitroslices. Intracellular recordings from morphologically identified cells and field potential recordings were used to characterize the physiology and pharmacology of ELL cells. Most intracellular recordings were from the Purkinje-like interneurons that are known as medium ganglion cells and from the two types of efferent neurons, large ganglion and large fusiform cells. Stimulation of primary afferent fibers elicits both excitatory and inhibitory effects in these cells, with the excitatory effects being mediated by both the AMPA and NMDA types of glutamate receptors and the inhibitory effects being mediated by both GABAAand glycine receptors. Parallel-fiber stimulation evokes an EPSP–IPSP sequence, with the EPSPs being mediated by both AMPA and NMDA receptors and the IPSPs being mediated by GABAAreceptors only. The parallel fiber-evoked EPSPs and IPSPs show marked paired-pulse facilitation. A large and unusually broad spike is recorded inside medium ganglion cells, and field potential responses suggest that this spike is propagated into the apical dendrites. The results provide essential information for understanding how peripheral and central inputs are integrated in ELL. |
| Databáze: | OpenAIRE |
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