Microvascular Perfusion Based on Arterial Spin Labeled Perfusion MRI as a Measure of Vascular Risk in Alzheimer's Disease
Autor: | Quan Zhang, Steven E. Arnold, Randall B. Stafford, Ze Wang, David A. Wolk, John A. Detre |
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Rok vydání: | 2012 |
Předmět: |
Male
Pathology medicine.medical_specialty Disease Article Cohort Studies White matter Alzheimer Disease Risk Factors medicine Humans Cognitive Dysfunction Prospective cohort study Stroke Aged Aged 80 and over medicine.diagnostic_test Microcirculation General Neuroscience Magnetic resonance imaging General Medicine Middle Aged medicine.disease Hyperintensity Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Cerebral blood flow Cerebrovascular Circulation Female Spin Labels Geriatrics and Gerontology Psychology Perfusion Magnetic Resonance Angiography |
Zdroj: | Journal of Alzheimer's Disease. 32:677-687 |
ISSN: | 1875-8908 1387-2877 |
DOI: | 10.3233/jad-2012-120964 |
Popis: | There is growing recognition of an interaction between cerebrovascular disease and Alzheimer's disease, but the mechanisms of this interaction remain poorly understood. While macroscopic stroke can clearly produce cognitive deficits and accelerate Alzheimer's disease, the prevalence and implications of microvascular disease in Alzheimer's disease pathogenesis has been harder to define. At present, white matter (WM) lesions, primarily defined as hyperintensities seen on T2-weighted magnetic resonance imaging (MRI), provide the best biomarker of cerebrovascular disease at the microvascular level. However, T2 hyperintensities in WM can also be caused by other mechanisms such as inflammation. Arterial spin labeled (ASL) perfusion MRI provides a noninvasive approach for quantifying cerebral blood flow (CBF). We explored CBF measurements with ASL in AD patients, mild cognitive impairment patients, and an age-matched control group to determine if CBF in gray matter or WM could be correlated with WM lesions, or to stratify patients by microvascular disease severity. In a retrospective sample, we were able to obtain credible measures of WM CBF using ASL MRI and observed trends suggesting that WM CBF may provide a useful biomarker of microvascular disease. Future prospective studies in larger cohorts with optimized ASL MRI protocols will be needed to validate these observations. |
Databáze: | OpenAIRE |
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