Percutaneous malathion absorption in the harvested perfused anuran pelvic limb

Autor:	Sharon K. Taylor, Ronald E. Baynes, Michael K. Stoskopf, Suzanne Kennedy-Stoskopf, Scott Willens, Gregory A. Lewbart
Rok vydání:	2006
Předmět:	Pharmacology Dorsum Percutaneous integumentary system Health Toxicology and Mutagenesis General Medicine Absorption (skin) Anatomy Thigh Biology Pelvic limb Toxicology chemistry.chemical_compound medicine.anatomical_structure chemistry Bullfrog Skin surface medicine Malathion
Zdroj:	Environmental Toxicology and Pharmacology. 22:263-267
ISSN:	1382-6689
DOI:	10.1016/j.etap.2006.04.009
Popis:	The objective of this study was to establish an accurate in vitro model for cutaneous absorption in anurans. The harvested perfused anuran pelvic limb (HPAPL) model maintains the anatomic and physiologic integrity of the skin from the pelvic limb, including the intact capillary network. Radiolabeled malathion was applied to the skin of the dorsal thigh, and perfusate was collected over a 6 h period. Residues from the skin surface, stratum externum, and dosed area beneath the stratum externum were analyzed. Kinetic parameters were calculated from these data. Absorption was significantly less for the HPAPL than previously reported for Teflon flow-through diffusion cells. However, partitioning effects were comparable. The HPAPL is an appropriate in vitro model for examining cutaneous absorption kinetics in the bullfrog.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15c96be476255048e3b343bf1bdd26f https://doi.org/10.1016/j.etap.2006.04.009 Zobrazit plný text záznamu Full Text from ScienceDirect