Inhibition of brain mitochondrial monoamine oxidases by the endogenous compound 5-hydroxyoxindole
| Autor: | Agnés Cane, Alexei Medvedev, Jean-Marie Launay, Marie-Claude Tournaire, Denis Barritault, Michèle Crumeyrolle-Arias |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Pharmacology
Isatin Indoles Monoamine Oxidase Inhibitors biology Monoamine oxidase Brain Endogeny Mitochondrion Biochemistry In vitro Mitochondria Oxindoles Rats chemistry.chemical_compound Monoamine neurotransmitter chemistry biology.protein Animals Monoamine oxidase B Monoamine oxidase A Monoamine Oxidase |
| Zdroj: | Biochemical pharmacology. 67(5) |
| ISSN: | 0006-2952 |
| Popis: | 5-Hydroxyoxindole is a recently identified endogenous compound. Its physiological role remains unclear but certain evidence exists, that it may share some regulatory properties with isatin, a known endogenous inhibitor of monoamine oxidase (MAO) type B (MAO-B). In this study several oxidized indoles were tested for their in vitro inhibition of MAO type A (MAO-A) and B of rat brain non-synaptic mitochondria. 5-Hydroxyoxindole was less potent MAO-A inhibitor (IC50 56.8 microM) than isatin (31.8 microM) and especially 5-hydroxyisatin (6.5 microM), but it was the only highly selective MAO-A inhibitor among the all compounds studied (IC50 MAO-A:IC50 MAO-B = 0.044). Thus, the in vitro data suggest that MAO-A may represent potential target for 5-hydroxyoxindole. |
| Databáze: | OpenAIRE |
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