The Impact of Previous Physical Training on Redox Signaling after Traumatic Brain Injury in Rats: A Behavioral and Neurochemical Approach
Autor: | Sara Marchesan Oliveira, Félix Alexandre Antunes Soares, Ana Flávia Furian, Ana Paula Pegoraro Zemolin, Mauro Robson Torres de Castro, Luiz Fernando Freire Royes, Luiz Fernando Almeida Silva, Leandro Rodrigo Ribeiro, Ana Paula de Oliveira Ferreira, Mauro Schneider Oliveira, Fernando Dobrachinski, Luís Roberto Hart da Silva, Mauro E.P. da Silveira, Michele Rechia Fighera, Jeferson Luis Franco, Fernando da Silva Fiorin |
---|---|
Rok vydání: | 2015 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Traumatic brain injury Hippocampus Physical exercise Hippocampal formation medicine.disease_cause Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Neurochemical Internal medicine Physical Conditioning Animal Brain Injuries Traumatic medicine Animals Learning Cognitive Dysfunction Rats Wistar chemistry.chemical_classification Reactive oxygen species Epilepsy Movement Disorders biology Behavior Animal medicine.disease Rats Disease Models Animal 030104 developmental biology Endocrinology chemistry Dentate Gyrus biology.protein Neurology (clinical) Psychology Neuroscience Oxidation-Reduction 030217 neurology & neurosurgery Oxidative stress Signal Transduction |
Zdroj: | Journal of neurotrauma. 33(14) |
ISSN: | 1557-9042 |
Popis: | Throughout the world, traumatic brain injury (TBI) is one of the major causes of disability, which can include deficits in motor function and memory, as well as acquired epilepsy. Although some studies have shown the beneficial effects of physical exercise after TBI, the prophylactic effects are poorly understood. In the current study, we demonstrated that TBI induced by fluid percussion injury (FPI) in adult male Wistar rats caused early motor impairment (24 h), learning deficit (15 days), spontaneous epileptiform events (SEE), and hilar cell loss in the hippocampus (35 days) after TBI. The hippocampal alterations in the redox status, which were characterized by dichlorofluorescein diacetate oxidation and superoxide dismutase (SOD) activity inhibition, led to the impairment of protein function (Na(+), K(+)-adenosine triphosphatase [ATPase] activity inhibition) and glutamate uptake inhibition 24 h after neuronal injury. The molecular adaptations elicited by previous swim training protected against the glutamate uptake inhibition, oxidative stress, and inhibition of selected targets for free radicals (e.g., Na(+), K(+)-ATPase) 24 h after neuronal injury. Our data indicate that this protocol of exercise protected against FPI-induced motor impairment, learning deficits, and SEE. In addition, the enhancement of the hippocampal phosphorylated nuclear factor erythroid 2-related factor (P-Nrf2)/Nrf2, heat shock protein 70, and brain-derived neurotrophic factor immune content in the trained injured rats suggests that protein expression modulation associated with an antioxidant defense elicited by previous physical exercise can prevent toxicity induced by TBI, which is characterized by cell loss in the dentate gyrus hilus at 35 days after TBI. Therefore, this report suggests that previous physical exercise can decrease lesion progression in this model of brain damage. |
Databáze: | OpenAIRE |
Externí odkaz: |