Drug Susceptibility Assessment in Stenotrophomonas Maltophilia Strains Isolated From the Blood of Organ Transplantation Recipients in a Warsaw Teaching Hospital During 2011 to 2014
| Autor: | Paulina Usarek, Grażyna Młynarczyk, Leszek Paczek, K. Szymanek-Majchrzak, Andrzej Młynarczyk, Andrzej Chmura, Anna Sawicka-Grzelak, K. Dobrzaniecka, Magdalena Durlik, Michał Ciszek, A. Kwiatkowski |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Stenotrophomonas maltophilia 030106 microbiology Ceftazidime Levofloxacin Microbial Sensitivity Tests Drug resistance Microbiology Clavulanic Acids 03 medical and health sciences 0302 clinical medicine Ciprofloxacin Drug Resistance Bacterial Trimethoprim Sulfamethoxazole Drug Combination medicine Humans Ticarcillin 030212 general & internal medicine Hospitals Teaching Transplantation biology Sulfamethoxazole Organ Transplantation biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Trimethoprim Transplant Recipients Anti-Bacterial Agents bacteria Surgery Gram-Negative Bacterial Infections medicine.drug |
| Zdroj: | Transplantation Proceedings. 48:1411-1413 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2016.01.072 |
| Popis: | Background Blood infections with multidrug-resistant Gram-negative carbapenem-resistant bacilli are particularly dangerous and challenging to treat in organ transplant recipients. Resistance to carbapenems may be acquired, for example, in Enterobacteriaceae, Pseudomonas, or Acinetobacter spp. or innate, for example, in Stenotrophomonas maltophilia. The purpose of this study was to analyze blood infections caused by S maltophilia in organ transplant recipients and to compare drug susceptibility of these bacteria and the same species isolated from the blood of other inpatients. Methods A total of 26 S maltophilia strains isolated from blood samples of 26 patients (including 14 liver or kidney transplant recipients) hospitalized during 2011 to 2014 were evaluated in this study. Antibiotic susceptibility was determined via E-test and disk diffusion methods. Results Stenotrophomonas maltophilia strains isolated from blood exhibited sensitivity to trimethoprim/sulfamethoxazole (100%), levofloxacin (96.2%), ciprofloxacin (92.3%), ticarcillin/clavulanic acid (80.8%), and ceftazidime (53.9%). Conclusions Because appropriate antibiotic therapy in the case of S maltophilia differs from the standard empirical therapy administered in the case of most other Gram-negative bacilli, early identification of this pathogen is of particular significance. The use of antibiotics to which this pathogen is sensitive eliminates the infection and helps avoid graft loss. |
| Databáze: | OpenAIRE |
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