ANTIBODY RESPONSE FOLLOWING RUBELLA IMMUNIZATION ANALYZED BY HLA TYPES
| Autor: | Junko Moriuchi, Toyoko Kano, Keizo Ishii, Yuko Nakai, Akemi Wakisaka, Naoki Nakazono, Harumi Sawada, Miki Aizawa |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Adolescent Hemagglutination business.industry Antibody titer Human leukocyte antigen Antibodies Viral medicine.disease Virology Rubella General Biochemistry Genetics and Molecular Biology Rubella vaccine Immune system Antibody response Immunization HLA Antigens Antibody Formation Immunology medicine Humans Female Rubella Vaccine business medicine.drug |
| Zdroj: | Japanese Journal of Medical Science and Biology. 33:103-106 |
| ISSN: | 1884-2828 0021-5112 |
| DOI: | 10.7883/yoken1952.33.103 |
| Popis: | Possible association between HLA antigens and antibody response to rubella vaccine was examined in 71 seronegative adult females, aged from 18 to 23, immunized with QEF vaccine. High responders (HAI antibody titer greater than or equal to 1:32) with HLA-B15 were significantly higher in frequency than those without HLA-B15 (p < 0.05). On the other hand, subjects with HLA-A9 had a tendency toward low immune responsiveness, including all the three non-responders. These results suggest that the antibody response to rubella vaccine may be influenced by the host-genetic factors relating to HLA antigens. |
| Databáze: | OpenAIRE |
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