Evaluation of accessory cell heterogeneity III. role of dendritic cells in the in vitro activation of the antibody response to soluble antigens
| Autor: | M. Kennedy, I. Sklenar, G. Ramila, P. Erb, G.H. Sunshine |
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| Rok vydání: | 1985 |
| Předmět: |
genetic structures
T-Lymphocytes T cell Lymphocyte Cooperation Immunology Antigen presentation Antigen-Presenting Cells Mice Inbred Strains Lymphocyte Activation Mice medicine Animals Immunology and Allergy Cytotoxic T cell Lymphocytes Antigen-presenting cell Mononuclear Phagocyte System B-Lymphocytes CD40 biology T-Lymphocytes Helper-Inducer Hematology Dendritic cell T helper cell Cell biology medicine.anatomical_structure Antibody Formation biology.protein Myeloid-derived Suppressor Cell Interleukin-2 |
| Zdroj: | Immunobiology. 169:424-435 |
| ISSN: | 0171-2985 |
| Popis: | Dendritic cells and macrophages obtained from spleen and peritoneal exudate were tested asaccessory cells for the activation of lymphokine production by T cells, for supporting T-B cooperation and for the induction of antigen-specific T helper cells. Dendritic cells as well as macrophages were able to activate T cells for interleukin-2 secretion and functioned as accessory cells in T-B cooperation, but only macrophages induced T helper cells, which cooperate with B cells by a linked recognition interaction, to soluble antigens. Dendritic cell- and antigen-activated T cells also did not help B cells in the presence of Con A supernatants which contained various T cell- and B cell-stimulatory factors. The failure of dendritic cells to differentiate memory into functional T helper cells, but their efficient accessory cell function in T-B cooperation, where functional T helper cells are already present, can be best explained by a differential accessory cell requirement for T helper cell activation dependent on the differentiation stage of the T helper cell. |
| Databáze: | OpenAIRE |
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