Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis
| Autor: | Yanxia Gao, Shiyuan Yu, Yi Li, Shigong Guo, Zeng Zheng Ge, Hua Dong Zhu, Xin Lu, Lina Zhao |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Encephalopathy Bioinformatics Pathogenesis Sepsis 03 medical and health sciences 0302 clinical medicine medicine Humans Pharmacology Neurotransmitter Agents Microglia Mechanism (biology) business.industry General Neuroscience Hyperammonemia Biological Transport Sepsis-Associated Encephalopathy Macrophage Activation medicine.disease 030104 developmental biology medicine.anatomical_structure Blood-Brain Barrier Etiology business 030217 neurology & neurosurgery |
| Zdroj: | CNSneurological disorders drug targets. 20(2) |
| ISSN: | 1996-3181 |
| Popis: | Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis. This review explores the pathogenesis of sepsis-associated encephalopathy, including its effects on the blood-brain barrier, microglia activation, mitochondrial dysfunction, the inflammatory medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia, and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopathy may allow the development of adjunctive therapies targeting its underlying mechanism and help develop preventative strategies. |
| Databáze: | OpenAIRE |
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