Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi
| Autor: | Carlos Robello, Ulrike Kemmerling, Natalia Anahí Juiz, Gabriela Libisch, Alejandro G. Schijman, Ileana Carrillo, Christian Castillo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chagas disease Trypanosoma cruzi Placenta 030231 tropical medicine Down-Regulation Gene Expression Biology Microarray Microbiology Host-Parasite Interactions lcsh:Infectious and parasitic diseases Transcriptome purl.org/becyt/ford/1 [https] Ciencias Biológicas 03 medical and health sciences 0302 clinical medicine Immune system MICROARRAY Pregnancy Gene expression parasitic diseases medicine Humans Chagas Disease lcsh:RC109-216 PLACENTA Child purl.org/becyt/ford/1.6 [https] GLOBAL GENE EXPRESSION Gene Innate immune system Gene Expression Profiling Research TRYPANOSOMA CRUZI Bioquímica y Biología Molecular medicine.disease biology.organism_classification Global gene expression Immunity Innate Up-Regulation Gene expression profiling 030104 developmental biology Infectious Diseases Tissue Array Analysis Parasitology Female CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Parasites & Vectors, Vol 11, Iss 1, Pp 1-13 (2018) Parasites & Vectors |
| Popis: | Background: Chagas disease is caused by Trypanosoma cruzi, a parasite endemic to Latin America. Most infections occur in children by vector or congenital transmission. Trypanosoma cruzi establishes a complexity of specific molecular parasite-host cell interactions to invade the host. However, most studies have been mainly focused on the interaction between the parasite and different cell types, but not on the infection and invasion on a tissue level. During congenital transmission, T. cruzi must cross the placental barrier, composed of epithelial and connective tissues, in order to infect the developing fetus. Here we aimed to study the global changes of transcriptome in the placental tissue after a T. cruzi challenge. Results: Strong changes in gene expression profiling were found in the different experimental conditions, involving the reprogramming of gene expression in genes involved in the innate immune response. Conclusions: Trypanosoma cruzi induces strong changes in genes involved in a wide range of pathways, especially those involved in immune response against infections. Fil: Castillo, Christian. Universidad de Chile; Chile Fil: Carrillo, Ileana. Universidad de Chile; Chile Fil: Libisch, Gabriela. Universidad de la República; Uruguay Fil: Juiz, Natalia Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Robello, Carlos. Universidad de la República; Uruguay Fil: Kemmerling, Ulrike. Universidad de Chile; Chile |
| Databáze: | OpenAIRE |
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