Relationship between fentanyl dosage and immune function in the postoperative period
| Autor: | Eduard Mayburd, Yifat Alcalay, Hanna Bessler, Israel Z. Yardeni, Benzion Beilin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cytotoxicity
Immunologic Male medicine.medical_treatment Interleukin-1beta Pharmacology Peripheral blood mononuclear cell Proinflammatory cytokine Fentanyl 03 medical and health sciences 0302 clinical medicine Immune system 030202 anesthesiology Humans Medicine Pharmacology (medical) Postoperative Period Aged Dose-Response Relationship Drug Interleukin-6 business.industry Immunity General Medicine Perioperative Middle Aged Interleukin-10 Analgesics Opioid Killer Cells Natural Anesthesiology and Pain Medicine Cytokine Anesthetic Interleukin-2 Female business 030217 neurology & neurosurgery Ex vivo medicine.drug |
| Zdroj: | Journal of Opioid Management. 4:27-33 |
| ISSN: | 1551-7489 |
| DOI: | 10.5055/jom.2008.0005 |
| Popis: | Background: Anesthesia and surgery are associated with impairment of the immune system expressed as an excessive proinflammatory immune response and suppression of cell mediated immunity. Opioids, an integral part of anesthetic technique, possess an inhibitory effect on both humoral and cellular immune responses. It was the aim of the present study to examine the effect of various doses of fentanyl on cytokine production during the perioperative period.Intervention: The effect of large (LDFA, 70-100 μg/kg), intermediate (IDFA, 23-30 μg/kg) and small (SDFA, 2-4 μg/kg) doses of fentanyl on the immune function in the postoperative period was investigated.Participants: Sixty patients, randomly assigned to one of the three groups according to the dose of fentanyl were included in the study.Methods: The ex vivo secretion of IL-1β, IL-2, IL-6, and IL-10 and NK cell cytotoxicity (NKCC) of peripheral blood mononuclear cells (PBMC) was tested before, and at 24, 48, and 72 hours following surgery.Results: The pattern of postoperative secretion of the proinflammatory cytokines IL-1β and IL-6 and that of the anti-inflammatory cytokine IL-10 differed significantly between patients receiving SDFA and those receiving IDFA and LDFA, but was similar between the last two groups. A similar suppression of NKCC and IL-2 secretion was observed in the three groups.Conclusions: The diminished proinflammatory cytokine response observed in patients treated by LDFA and IDFA suggests that although more stable immune function can be achieved by those methods in comparison with SDFA, it is recommendable to apply IDFA to avoid the side effects that might be observed using LDFA method. |
| Databáze: | OpenAIRE |
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