Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles

Autor:	Mehrdad Faizi, Afshin Dalvandi, Sayyed Abbas Tabatabai, Abbas Kebriaeezadeh, Abbas Shafiee, Nazila Mehrabi, Ali Almasirad
Rok vydání:	2004
Předmět:	Stereochemistry medicine.medical_treatment Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science Ether Biochemistry Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Drug Discovery medicine Structure–activity relationship Molecular Biology Oxadiazoles Molecular Structure GABAA receptor Chemistry Organic Chemistry General Medicine Triazoles Anticonvulsant Mechanism of action Benzene derivatives Triazole derivatives Molecular Medicine Anticonvulsants medicine.symptom
Zdroj:	Bioorganicmedicinal chemistry letters. 14(24)
ISSN:	0960-894X
Popis:	A series of new 2-substituted-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles has been synthesized and screened for their anticonvulsant activities. Compound 3 shows considerable anticonvulsant activity both in PTZ and MES models. It seems that this effect is mediated by benzodiazepine receptors and other unknown mechanism, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e152ebb210a9544a8479c5aa71d73d7c https://pubmed.ncbi.nlm.nih.gov/15546729 Zobrazit plný text záznamu Full Text from ScienceDirect