Ovine prenatal growth restriction impacts glucose metabolism and body composition throughout life in both sexes
| Autor: | Clare Lesley Adam, John S. Milne, Raymond Aitken, Graham W. Horgan, Jacqueline Wallace |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine Embryology Offspring medicine.medical_treatment Physiology 030209 endocrinology & metabolism Growth Weaning Carbohydrate metabolism Biology Body fat percentage 03 medical and health sciences Absorptiometry Photon Overnutrition 0302 clinical medicine Endocrinology Pregnancy medicine Animals Body Size Insulin Fetal Growth Retardation Sheep Pregnancy Outcome Area under the curve Obstetrics and Gynecology Cell Biology medicine.disease Glucose 030104 developmental biology Reproductive Medicine Prenatal Exposure Delayed Effects Body Composition Female |
| Zdroj: | Reproduction. 156:103-119 |
| ISSN: | 1741-7899 1470-1626 |
| DOI: | 10.1530/rep-18-0048 |
| Popis: | Low birthweight is a risk factor for later adverse health. Here the impact of placentally mediated prenatal growth restriction followed by postnatal nutrient abundance on growth, glucose metabolism and body composition was assessed in both sexes at key stages from birth to mid-adult life. Singleton-bearing adolescent dams were fed control or high nutrient intakes to induce normal or growth-restricted pregnancies respectively. Restricted lambs had ~40% reduced birthweight. Fractional growth rates were higher in restricted lambs of both sexes predominantly during suckling/juvenile phases. Thereafter, rates and patterns of growth differed by sex. Absolute catch-up was not achieved and restricted offspring had modestly reduced weight and stature at mid-adulthood necropsy (~109 weeks). Dual-energy X-ray absorptiometry revealed lower bone mineral density in restricted vs normal lambs at 11, 41, 64 and 107 weeks, with males > females from 41 weeks onwards. Body fat percentage was higher in females vs males throughout, in restricted vs normal lambs at weaning (both sexes) and in restricted vs normal females at mid-adulthood. Insulin secretion after glucose challenge was greater in restricted vs normal of both sexes at 7 weeks and in restricted males at 32 weeks. In both sexes, fasting glucose concentrations were greater in restricted offspring across the life course, while glucose area under the curve after challenge was higher in restricted offspring at 32, 60, 85 and 106 weeks, indicative of persistent glucose intolerance. Therefore, prenatal growth restriction has negative consequences for body composition and metabolism throughout the life course with the effects modulated by sex differences in postnatal growth rates, fat deposition and bone mass accrual. |
| Databáze: | OpenAIRE |
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