Phase-dependent offline enhancement of human motor memory
| Autor: | Jessica Stimely, Christoph Zrenner, Leonardo G. Cohen, Mary K Vollmer, Gina Norato, Ethan R. Buch, Sara J. Hussain, Ulf Ziemann |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Oscillations genetic structures Motor learning medicine.medical_treatment education Biophysics Phase (waves) Neurosciences. Biological psychiatry. Neuropsychiatry Audiology Trough (economics) behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Rhythm Memory medicine Humans 0501 psychology and cognitive sciences Motor skill Mathematics General Neuroscience 05 social sciences Motor Cortex Evoked Potentials Motor Hand Transcranial Magnetic Stimulation Transcranial magnetic stimulation Phase Offline learning Neurology (clinical) Sensorimotor Cortex Primary motor cortex 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Brain Stimulation, Vol 14, Iss 4, Pp 873-883 (2021) |
| ISSN: | 1876-4754 |
| Popis: | Background Skill learning engages offline activity in the primary motor cortex (M1). Sensorimotor cortical activity oscillates between excitatory trough and inhibitory peak phases of the mu (8–12 Hz) rhythm. We recently showed that these mu phases influence the magnitude and direction of neuroplasticity induction within M1. However, the contribution of M1 activity during mu peak and trough phases to human skill learning has not been investigated. Objective To evaluate the effects of phase-dependent TMS during mu peak and trough phases on offline learning of a newly-acquired motor skill. Methods On Day 1, three groups of healthy adults practiced an explicit motor sequence learning task with their non-dominant left hand. After practice, phase-dependent TMS was applied to the right M1 during either mu peak or mu trough phases. The third group received sham TMS during random mu phases. On Day 2, all subjects were re-tested on the same task to evaluate offline learning. Results Subjects who received phase-dependent TMS during mu trough phases showed increased offline skill learning compared to those who received phase-dependent TMS during mu peak phases or sham TMS during random mu phases. Additionally, phase-dependent TMS during mu trough phases elicited stronger whole-brain broadband oscillatory power responses than phase-dependent TMS during mu peak phases. Conclusions We conclude that sensorimotor mu trough phases reflect brief windows of opportunity during which TMS can strengthen newly-acquired skill memories. |
| Databáze: | OpenAIRE |
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