Human Cytomegalovirus Enhances A. actinomycetemcomitans Adherence to Cells
| Autor: | I. Sliepen, S. Kinder Haake, Marc Quirynen, M. Van Ranst, J. Van Eldere, Wim Teughels, Paula Fives-Taylor |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
0301 basic medicine
Human cytomegalovirus viruses Cytomegalovirus medicine.disease_cause Aggregatibacter actinomycetemcomitans Bacterial Adhesion hCMV Microbiology Pathogenesis HeLa 03 medical and health sciences 0302 clinical medicine medicine Humans adherence Periodontitis General Dentistry Cells Cultured biology polymicrobial Histocompatibility Antigens Class II Epithelial Cells A actinomycetemcomitans 030206 dentistry Viral Load medicine.disease biology.organism_classification Virology epithelial cells In vitro stomatognathic diseases Actinobacillus actinomycetemcomitans 030104 developmental biology Microscopy Fluorescence human cytomegalovirus Superinfection Actinobacillus Viral load HeLa Cells |
| Zdroj: | Journal of Dental Research. 86:175-180 |
| ISSN: | 1544-0591 0022-0345 |
| Popis: | Adherence of Actinobacillus actinomycetemcomitans to epithelial cells is an important step in periodontal disease pathogenesis. Recent publications describe the subgingival presence of a wide array of viruses [e.g., human cytomegalo-virus (hCMV)]. Since viruses can increase cellular susceptibility for bacterial adherence, we investigated whether hCMV renders epithelial cells more prone to adherence by Actinobacillus actinomycetemcomitans. Cultivated HeLa and primary epithelial cells were shown to be semi-permissive for hCMV infection, which resulted in increased bacterial adherence. This increase correlated with viral concentrations, was evident in all Actinobacillus actinomycetemcomitans strains examined, and increased during the first 24 hrs, followed by a slight decrease. Immediate early antigen expression was not correlated with the increased adherence of Actinobacillus actinomycetemcomitans. The results confirmed our hypothesis that the adherence of Actinobacillus actinomycetemcomitans is influenced by hCMV in vitro. ispartof: Journal of Dental Research vol:86 issue:2 pages:175-180 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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