Antireproductive effect of the calcium channel blocker amlodipine in male rats
| Autor: | Juliana Mazzonetto Teófilo, Severina Alves Almeida, J. A. Anselmo Franci, Luiz Guilherme Brentegani, Lamano-Carvalho Tl |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
endocrine system medicine.medical_specialty medicine.drug_class Calcium channel blocker Biology Toxicology Pathology and Forensic Medicine Internal medicine Testis medicine Animals Testosterone Amlodipine Rats Wistar Infertility Male Sperm Count urogenital system Cell Biology General Medicine Luteinizing Hormone Sertoli cell Calcium Channel Blockers Prolactin Rats Seminiferous tubule medicine.anatomical_structure Endocrinology Follicle Stimulating Hormone Luteinizing hormone Spermatogenesis medicine.drug |
| Zdroj: | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 52(4) |
| ISSN: | 0940-2993 |
| Popis: | Summary The purpose of the present study was to investigate whether treatment of male rats with the calcium antagonist amlodipine, used in the treatment of hypertension and angina, interferes with the reproductive function of male rats. Amlodipine treatment (0.04 mg amlodipine besylate/rat/day for 30 days) decreased plasma follicle-stimulating hormone and testosterone but not luteinizing hormone or prolactin concentrations (measured by double-antibody radioimmuno-assay). A significant reduction (23%) was observed in sperm density (sperm suspension collected from the cauda epididymidis) as well as in the amount of mature spermatids (14%) and Sertoli cells (9%) counted in seminiferous tubule cross-sections (400 × magnification). The results reveal the deleterious effects of subacute amlodipine treatment on the reproductive function of male rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect