Transforming growth factor-beta (TGF-beta) protein levels are not elevated in the blood or bile of patients with primary sclerosing cholangitis: a pilot study
| Autor: | J K Watt, G Sandha, K. Hawkins, Yuewen Gong, Julia Uhanova, Manna Zhang, Jeremy Lipschitz, G. Y. Minuk |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Physiology Cholangitis Sclerosing Enzyme-Linked Immunosorbent Assay Pilot Projects digestive system Gastroenterology Severity of Illness Index Primary sclerosing cholangitis Liver disease Cholangiography Cholestasis Fibrosis Transforming Growth Factor beta Internal medicine medicine Bile Humans medicine.diagnostic_test business.industry Hepatology Middle Aged medicine.disease Alkaline Phosphatase Biliary tract Case-Control Studies Female business Transforming growth factor |
| Zdroj: | Digestive diseases and sciences. 49(1) |
| ISSN: | 0163-2116 |
| Popis: | Primary sclerosing cholangitis (PSC) is a chronic cholestatic disorder of unknown etiology characterized by progressive fibrosis and stricturing of the biliary tract. Transforming growth factor-beta (TGF-beta) is a family of cytokines produced by biliary tract epithelial cells that promote fibrinogenesis. Our objective was to determine whether TGF-beta levels are increased in the blood and/or bile of PSC patients compared to patients with other causes of obstructed biliary tracts (controls). Serum and bile TGF-beta levels were documented by enzyme-linked immunoassay in 10 adult PSC and 10 control patients obtained at the time of endoscopic retrograde cholangiography. Serum and bile TGF-beta levels were similar in the two groups (PSC versus control sera, 33.4 +/- 4.3 versus 27.5 +/- 7.7 ng/ml, and bile, 367 +/- 275 versus 457 +/- 247 ng/mg, respectively). Serum and bile TGF-beta levels are not increased in patients with PSC. Hence, the results of this pilot study do not support the hypotheses that PSC is caused by dysregulated TGF-beta expression. |
| Databáze: | OpenAIRE |
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