Retraction note: Cutaneous mast cell tumor (Mastocytoma): cyto-histopathological and haematological investigations
| Autor: | Ali Mohammad Bahrami, Mobin Koohestani, Javad Javanbakht, Behnam Pedram, Ehsan Hosseini, Radmehr Shafiee, Najme Jaberi Moghaddam, Fatemeh Emami Ghomi, Mohammad Hossein Jaberi Moghaddam |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Histology 040301 veterinary sciences Cytodiagnosis Volutin granules Biology Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine Dermis Cytology medicine Animals Dog Diseases Grading (tumors) Mastocytoma Skin Mastocytoma 04 agricultural and veterinary sciences General Medicine Mast cell medicine.disease Retraction Note medicine.anatomical_structure Cytoplasm 030220 oncology & carcinogenesis Mitotic Figure Female |
| Zdroj: | Diagnostic Pathology |
| ISSN: | 1746-1596 |
| DOI: | 10.1186/s13000-016-0576-1 |
| Popis: | Cutaneous mast cell tumours (MCTs) are the most common skin tumours in dogs. Due to the prevalence of canine MCTs and the variable biologic behavior of this disease, accurate prognostication and a thorough understanding of MCT biology are critical for the treatment of this disease. A cytologic diagnosis of mast cell tumor with evidence of prior hemorrhage was made, and the masses were surgically removed. Cytological evaluation of fine-needle aspirates from the cutaneous mass from the axillary comprised many well-differentiated, highly granulated mast cells with moderate numbers of eosinophils. Nuclei were varied in size and shape with high nuclear’to’cytoplasmic ratio, prominent nucleoli, marked atypical and mitotic figures. Microscopically, mass consisted of sheets of neoplastic round cells that formed nonencapsulated nodules in the dermis and infiltrated into the adjacent dermal collagen, and also there was diffuse subcutis invasion of round to pleomorphic tumor cells. Tumor cells had moderate to abundant cytoplasm, round to ovoid nuclei with scattered chromatin, and mitotic figures. In this tumor, cytoplasmic granules showed atypical metachromasia. In addition, eosinophils were scattered among the mast cells at the periphery of the nodules. The presence of eosinophils and the observation, at high magnification, of cells with cytoplasmic metachromatic granules. Invasion of the deep subcutaneous fat or cutaneous muscles were a common feature of grade III tumour. Finally, a diagnosis of grade III cutaneous mast cell tumor was made. The virtual slide(s) of this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4755249151157024 . |
| Databáze: | OpenAIRE |
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