Faster cognitive decline in dementia due to Alzheimer disease with clinically undiagnosed Lewy body disease
| Autor: | Charles H. Adler, Bryan M. Spann, Brett Cutler, Sandra A. Jacobson, Bryan K. Woodruff, Javon Oliver, Lisa R. Nicholson, Geoffrey L. Ahern, Eric M. Reiman, Michael Malek-Ahmadi, Steven Z. Rapscak, Richard J. Caselli, Jiong Shi, Kewei Chen, Christine Belden, Edward Zamrini, John N. Caviness, Marwan N. Sabbagh, Jasmine Curry, Michael J. Glass, David Shprecher, Lucia I. Sue, Richard Arce, Douglas G. Walker, Anthony Intorcia, Lih-Fen Lue, Geidy E. Serrano, Kathy E. Long, Holly A. Shill, Michael Callan, Erika Driver-Dunckley, Pierre N. Tariot, Shyamal H. Mehta, Thomas G. Beach, Kathryn J. Davis, Jessica E. Walker |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Social Sciences Kaplan-Meier Estimate Disease Alzheimer's Disease Pathology and Laboratory Medicine 0302 clinical medicine Animal Cells Medicine and Health Sciences Prevalence Psychology Cognitive decline Neuropathology Cognitive Impairment Neurons 0303 health sciences Movement Disorders Multidisciplinary Cognitive Neurology Parkinsonism Neurodegenerative Diseases Parkinson Disease Neurology Medicine Female Cellular Types Alzheimer's disease Research Article Lewy Body Disease medicine.medical_specialty Science Cognitive Neuroscience 03 medical and health sciences Diagnostic Medicine Neuropsychology Alzheimer Disease Internal medicine Mental Health and Psychiatry mental disorders medicine Humans Dementia Cognitive Dysfunction Neuropsychological Testing Aged 030304 developmental biology Behavior business.industry Dementia with Lewy bodies Biology and Life Sciences Cell Biology medicine.disease Comorbidity Anatomical Pathology Cellular Neuroscience Cognitive Science Lewy Bodies business 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 6, p e0217566 (2019) |
| ISSN: | 1932-6203 |
| Popis: | BackgroundNeuropathology has demonstrated a high rate of comorbid pathology in dementia due to Alzheimer's disease (ADD). The most common major comorbidity is Lewy body disease (LBD), either as dementia with Lewy bodies (AD-DLB) or Alzheimer's disease with Lewy bodies (AD-LB), the latter representing subjects with ADD and LBD not meeting neuropathological distribution and density thresholds for DLB. Although it has been established that ADD subjects with undifferentiated LBD have a more rapid cognitive decline than those with ADD alone, it is still unknown whether AD-LB subjects, who represent the majority of LBD and approximately one-third of all those with ADD, have a different clinical course.MethodsSubjects with dementia included those with "pure" ADD (n = 137), AD-DLB (n = 64) and AD-LB (n = 114), all with two or more complete Mini Mental State Examinations (MMSE) and a full neuropathological examination.ResultsLinear mixed models assessing MMSE change showed that the AD-LB group had significantly greater decline compared to the ADD group (β = -0.69, 95% CI: -1.05, -0.33, pConclusionsThe probable cause of LBD clinical detection failure is the lack of a sufficient set of characteristic core clinical features. Core DLB clinical features were not more common in AD-LB as compared to ADD. Clinical identification of ADD with LBD would allow stratified analyses of ADD clinical trials, potentially improving the probability of trial success. |
| Databáze: | OpenAIRE |
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