Pathways for Sensing and Responding to Hydrogen Peroxide at the Endoplasmic Reticulum
| Autor: | Carolyn S. Sevier, Jennifer M Roscoe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
BiP
Calcium pump hydrogen peroxide Review IRE1 Endoplasmic Reticulum reactive oxygen species (ROS) Peroxide Models Biological chemistry.chemical_compound Molecular chaperone BiP Animals Humans Hydrogen peroxide unfolded protein response (UPR) redox signaling lcsh:QH301-705.5 chemistry.chemical_classification Reactive oxygen species Endoplasmic reticulum General Medicine Transmembrane protein endoplasmic reticulum (ER) SERCA2 chemistry lcsh:Biology (General) Biophysics cysteine oxidation Cysteine Molecular Chaperones Signal Transduction |
| Zdroj: | Cells, Vol 9, Iss 2314, p 2314 (2020) Cells |
| ISSN: | 2073-4409 |
| Popis: | The endoplasmic reticulum (ER) has emerged as a source of hydrogen peroxide (H2O2) and a hub for peroxide-based signaling events. Here we outline cellular sources of ER-localized peroxide, including sources within and near the ER. Focusing on three ER-localized proteins—the molecular chaperone BiP, the transmembrane stress-sensor IRE1, and the calcium pump SERCA2—we discuss how post-translational modification of protein cysteines by H2O2 can alter ER activities. We review how changed activities for these three proteins upon oxidation can modulate signaling events, and also how cysteine oxidation can serve to limit the cellular damage that is most often associated with elevated peroxide levels. |
| Databáze: | OpenAIRE |
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