Induction of antiphospholipid autoantibodies by immunization with beta 2 glycoprotein I (apolipoprotein H)
| Autor: | Jiaying Wen, K. B. Elkon, Azzudin E. Gharavi, L. R. Sammaritano |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Mice
immune system diseases Animals Humans Medicine Beta 2-Glycoprotein I skin and connective tissue diseases Phospholipids Autoantibodies Glycoproteins chemistry.chemical_classification Lupus erythematosus biology business.industry Autoantibody General Medicine medicine.disease Apolipoproteins Immunization chemistry beta 2-Glycoprotein I Immunology biology.protein Cattle lipids (amino acids peptides and proteins) Rabbits Antibody business Glycoprotein Apolipoprotein H Research Article Anti-SSA/Ro autoantibodies |
| Zdroj: | Journal of Clinical Investigation. 90:1105-1109 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci115927 |
| Popis: | A subset of patients with systemic lupus erythematosus has autoantibodies to acidic phospholipids. Since lipids are poor immunogens, the mechanism responsible for the induction of these antibodies is unclear. Immunization of a normal rabbit and normal mice with purified human beta 2-glycoprotein I (apolipoprotein H) resulted in the production of high levels of two non-cross-reactive antibody populations, anti-apolipoprotein H, and antiphospholipid. The antiphospholipid antibodies had binding specificities indistinguishable from autoantibodies obtained from human and murine lupus. These findings suggest a novel mechanism for the induction of antiphospholipid autoantibodies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|