Lipidome of plasma lipoproteins and liver is zinc- modulated in High fat diet treated mice
| Autor: | Ioannis-Konstantinos Deligiannis, Eleni Bairaktari, Vasiliki Kalfakakou, Patra Vezyraki, Panagiotis Lekkas, Christina Kostara, Charalampos Angelidis |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Lipoproteins chemistry.chemical_element Zinc Diet High-Fat Biochemistry Inorganic Chemistry 03 medical and health sciences Mice Internal medicine medicine Animals 030109 nutrition & dietetics Wild type Lipidome medicine.disease Lipids Metabolic pathway 030104 developmental biology Endocrinology chemistry Liver Zinc deficiency Molecular Medicine lipids (amino acids peptides and proteins) Composition (visual arts) Intracellular Drug metabolism |
| Zdroj: | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 50 |
| ISSN: | 1878-3252 |
| Popis: | Zinc (Zn) and Zn-transcription Factors regulate the metabolic pathways of lipids and glucose, consequently nutritional zinc deficiency or excess, activates stress pathways and deranges the hepatic metabolism of lipids. High fat diet (HFD) also leads to lipids’ profile disorders as well as to intracellular free radicals (FR) accumulation and finally to metabolic stress-syndrome. Study of nutritional Zn effects on the lipidome of plasma lipoproteins and liver, in HFD-mice, was the aim of the present research. Three Zn enriched HF-Diets as follows, 3 mg/kg feed (Zn deficient diet), 30 mg/kg feed (Zn sufficient diet), 300mgZn /kg feed (Zn excess diet) (Mucedola s.r.l Italy-55% cal) were applied respectively to three groups of male wild type (wt) mice (Hybrid F1/F1),C57Bl/6xCBA, one month old, for 10 weeks. Accordingly, mice body weight rate and 1H-NMR spectrum analysis of liver extracts and plasma HDL and non-HDL lipoproteins were evaluated at the end of the experimental period. It is concluded that Zn sufficient diet (30 mg/Kg Feed) creates a highly protective lipidomic profile on plasma and liver lipoproteins of HFD-mice, related to significantly increased antiatherogenic indicators in lipids’ composition, compared to mice in nutritional Zn deficiency or excess. |
| Databáze: | OpenAIRE |
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