Are oxidative stress markers associated with unexplained male infertility?
| Autor: | Mauricio Camargo, Angela P. Cadavid, W. Cardona Maya, B.J.M. Mayorga-Torres, S.S. Du Plessis |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Urology media_common.quotation_subject 030232 urology & nephrology Fertility Semen DNA Fragmentation Semen analysis Biology medicine.disease_cause Antioxidants Male infertility Andrology 03 medical and health sciences 0302 clinical medicine Endocrinology medicine Humans Sperm motility Infertility Male media_common Membrane Potential Mitochondrial 030219 obstetrics & reproductive medicine medicine.diagnostic_test Sperm Count General Medicine medicine.disease Sperm Spermatozoa Chromatin Semen Analysis Sperm Motility DNA fragmentation Lipid Peroxidation Reactive Oxygen Species Oxidative stress Biomarkers |
| Zdroj: | Andrologia. 49(5) |
| ISSN: | 1439-0272 |
| Popis: | Summary Male infertility can be responsible for up to 20% of the cases attending fertility consultation facilities; nonetheless, the underlying molecular mechanisms that could explain it are still elusive. Therefore, we aimed to evaluate conventional and functional parameters of semen samples from patients who presented with male infertility of unknown origin. Conventional semen parameters and functional parameters (i.e. intracellular reactive oxygen species production, mitochondrial membrane potential, sperm chromatin structure assay, sperm membrane lipid peroxidation and antioxidant capacity of seminal plasma) were evaluated on semen samples from 54 healthy donors, 23 patients with idiopathic infertility and 34 fertile controls. No significant differences were observed in the conventional seminal parameters between the fertile and infertile men. However, increased intracellular reactive oxygen species (ROS) production and DNA fragmentation were observed in the infertile patients compared to the fertile group. Alterations in intracellular ROS production and DNA fragmentation could be associated with male idiopathic infertility. These parameters could eventually distinguish both groups more accurately than the conventional parameters. Our current results are encouraging, and the efficacy of these parameters in the clinical settings needs to be further assessed to establish their predictive potential as a marker of unexplained male infertility. |
| Databáze: | OpenAIRE |
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