Effects of Nitric Oxide on Red Blood Cells: Changes in Erythrocyte Resistance to Hypotonic Hemolysis and Potassium Efflux by Experimental Maneuvers That Decrease Nitric Oxide
| Autor: | Guillermina Blum, Juan R. Mosquera, V. Casado, L. Sanchez, A. Riesco, I. Millás, Antonio López Farré, C Caramelo, J. Outeirino, S. Casado, B. Monzu |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Erythrocytes Arginine Neutrophils Potassium Biophysics chemistry.chemical_element Pharmacology Nitric Oxide Hemolysis Biochemistry Nitric oxide chemistry.chemical_compound Guanosine monophosphate medicine Animals Humans Rats Wistar Cyclic GMP Molecular Biology omega-N-Methylarginine Cell Biology medicine.disease Rats Kinetics Red blood cell NG-Nitroarginine Methyl Ester medicine.anatomical_structure Hypotonic Solutions chemistry Tonicity Female Efflux |
| Zdroj: | Biochemical and Biophysical Research Communications. 199:447-454 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1994.1249 |
| Popis: | To determine the role of nitric oxide (NO)-dependent mechanisms on erythrocyte properties, we exposed red cells to L-arginine competitive analogues, 8Br-cyclic guanosine monophosphate (8Br-cGMP) and neutrophil-eliminating filters. These treatments significantly decreased hypotonic hemolysis, increased potassium efflux and caused a spiculate change in erythrocyte morphology. These effects were related to a decrease of NO caused by the three types of treatments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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