Human acute Chagas disease: changes in factor VII, activated protein C and hepatic enzymes from patients of oral outbreaks in Pará State (Brazilian Amazon)
| Autor: | Dina Antunes, D Souza, Otacilio C. Moreira, Igor C. A. Lima, Désio Aurélio Farias-de-Oliveira, João Pedro Lobo, Ernesto de Meis, Wilson Savino, José Rodrigues Coura, Angela Cristina Verissimo Junqueira, Valéria Regina Cavalcante dos Santos, Juliana de Meis |
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| Rok vydání: | 2019 |
| Předmět: |
myalgia
Male Chagas disease RC955-962 coagulation factors Parasite load Gastroenterology Parasite Load chemistry.chemical_compound parasite load 0302 clinical medicine Arctic medicine. Tropical medicine oral transmission Prospective Studies biology Factor VII Alanine Transaminase Middle Aged QR1-502 liver enzymes Liver Benznidazole Acute Disease Female medicine.symptom Brazil medicine.drug Microbiology (medical) Adult medicine.medical_specialty Short Communication 030231 tropical medicine Factor VIIa Microbiology Transaminase 03 medical and health sciences Internal medicine medicine Humans Aspartate Aminotransferases Trypanosoma cruzi business.industry medicine.disease biology.organism_classification chemistry Case-Control Studies business Protein C Biomarkers |
| Zdroj: | Memórias do Instituto Oswaldo Cruz Memórias do Instituto Oswaldo Cruz, Volume: 115, Article number: e190364, Published: 27 FEB 2020 Memórias do Instituto Oswaldo Cruz. |
| ISSN: | 1678-8060 |
| Popis: | Oral transmission of Chagas disease has been increasing in Latin American countries. The present study aimed to investigate changes in hepatic function, coagulation factor levels and parasite load in human acute Chagas disease (ACD) secondary to oral Trypanosoma cruzi transmission. Clinical and epidemiological findings of 102 infected individuals attended in the State of Para from October 2013 to February 2016 were included. The most common symptoms were fever (98%), asthenia (83.3%), face and limb edema (80.4%), headache (74.5%) and myalgia (72.5%). The hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of 30 ACD patients were higher compared with controls, and this increase was independent of the treatment with benznidazole. Moreover, ACD individuals had higher plasma levels of activated protein C and lower levels of factor VII of the coagulation cascade. Patients with the highest parasite load had also the most increased transaminase levels. Also, ALT and AST were associated moderately (r = 0.429) and strongly (r = 0.595) with parasite load respectively. In conclusion, the present study raises the possibility that a disturbance in coagulation and hepatic function may be linked to human ACD. |
| Databáze: | OpenAIRE |
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