Latent inhibition, but not prepulse inhibition, is reduced during withdrawal from an escalating dosage schedule of amphetamine

Autor:	C A, Murphy, M, Fend, H, Russig, J, Feldon
Rok vydání:	2001
Předmět:	Amphetamine Disease Models Animal Inhibition Psychological Behavioral Neuroscience Schizophrenia Animals Central Nervous System Stimulants Rats Wistar Stereotyped Behavior Rats Substance Withdrawal Syndrome
Zdroj:	Behavioral Neuroscience. 115:1247-1256
ISSN:	1939-0084 0735-7044
Popis:	The enhanced locomotor and stereotypic responses of the rat to repeated amphetamine (AMPH) administration are considered to be an animal model of positive schizophrenic symptoms. In contrast, behaviors observed during withdrawal from repeated AMPH are believed to model depression or anxiety. In the present study, the authors tested whether AMPH withdrawal might also elicit behaviors consistent with animal models of schizophrenia, specifically, disruptions in latent inhibition (LI) of 2-way active avoidance and prepulse inhibition (PPI) of startle. Rats treated with escalating doses of AMPH (6 days, 1-5 mg/kg ip) or saline were tested for LI and PPI during withdrawal. LI was eliminated by prior AMPH treatment in rats tested at 4, 13, and 28 days of withdrawal. In contrast, PPI did not differ between AMPH and control groups. These results support an interrelationship between repeated-AMPH and LI-disruption, but not PPI-disruption, models of schizophrenia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e138f4822cc79ef8d9686fb7b329f1a6 https://doi.org/10.1037/0735-7044.115.6.1247 Zobrazit plný text záznamu