Levamisole adulterated cocaine associated ANCA vasculitis: review of literature and update on pathogenesis
| Autor: | Sam Kant, Duvuru Geetha, Jihad Alhariri, Qiuyu Jin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Drug
lcsh:Internal medicine levimasole Anca vasculitis business.industry media_common.quotation_subject Cocaine contaminant cocaine Review Article Levamisole Anti-neutrophil cytoplasmic antibody Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Immunology Internal Medicine medicine cardiovascular diseases lcsh:RC31-1245 business media_common medicine.drug |
| Zdroj: | Journal of Community Hospital Internal Medicine Perspectives Journal of Community Hospital Internal Medicine Perspectives, Vol 8, Iss 6, Pp 339-344 (2018) |
| ISSN: | 2000-9666 |
| Popis: | Levamisole is an antihelminth drug and a common cocaine contaminant, present in an estimated 71% of cocaine samples in the US. Levamisole-contaminated cocaine has been linked to an ANCA-associated vasculitis with cutaneous, renal, and pulmonary manifestations. We report the case of a 46 year old woman with known cocaine exposure who presents with recurrent, large purpuric and maculopapular rash of the extremities and face and review existing cases of levamisole/cocaine-associated ANCA vasculitis, We summarize the clinical presentation, treatment, and outcomes of levamisole induced vasculitis. There is emerging research on pathogenesis relating to neutrophil extracellular traps (NETs). We review studies implicating role of NETs in the pathogenesis of levamisole induced vasculitis. Further research to explore the use of NETs as therapeutic targets in drug induced vasculitis is needed. |
| Databáze: | OpenAIRE |
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