Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis
| Autor: | Linda Ariza-McNaughton, Adam L. Bermange, Jonathan D. Leslie, Ryan Mcadow, Stephen L. Johnson, Julian Lewis |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Vascular Endothelial Growth Factor A
Angiogenesis Notch signaling pathway Neovascularization Physiologic Biology Vascular remodelling in the embryo chemistry.chemical_compound Cell Movement Animals Molecular Biology Zebrafish Cell Proliferation Receptors Notch Intracellular Signaling Peptides and Proteins Endothelial Cells Membrane Proteins Zebrafish Proteins biology.organism_classification Embryonic stem cell Cell biology Vascular endothelial growth factor Vascular endothelial growth factor B chemistry Vascular endothelial growth factor C cardiovascular system Endothelium Vascular Developmental Biology Signal Transduction |
| Zdroj: | Development (Cambridge, England). 134(5) |
| ISSN: | 0950-1991 |
| Popis: | Notch signalling by the ligand Delta-like 4 (Dll4) is essential for normal vascular remodelling, yet the precise way in which the pathway influences the behaviour of endothelial cells remains a mystery. Using the embryonic zebrafish, we show that, when Dll4-Notch signalling is defective, endothelial cells continue to migrate and proliferate when they should normally stop these processes. Artificial overactivation of the Notch pathway has opposite consequences. When vascular endothelial growth factor (Vegf) signalling and Dll4-Notch signalling are both blocked, the endothelial cells remain quiescent. Thus, Dll4-Notch signalling acts as an angiogenic `off' switch by making endothelial cells unresponsive to Vegf. |
| Databáze: | OpenAIRE |
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