Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU
| Autor: | Riestra, Sabino, Taxonera, Carlos, Zabana, Yamile, Carpio, Daniel, Chaparro, María, Barrio, Jesús, Rivero, Montserrat, López Sanroman, Antonio, Esteve, María, Francisco, Ruth de, Bastida, Guillermo, García López, Santiago, Mañosa, Miriam, Martin Arranz, María Dolores, Pérez Calle, José Lázaro, Guardiola, Jordi, Muñoz, Fernando, Arranz, Laura, Cabriada, José Luis, García Sepulcre, Mariana Fe, Navarro, Mercè, Montoro Huguet, Miguel Ángel, Ricart, Elena, Bermejo, Fernando, Calvet, Xavier, Piqueras, Marta, Garcia Planella, Esther, Márquez, Lucía, Mínguez, Miguel, Van Domselar, Manuel, Bujanda, Luis, Aldeguer, Xavier, Sicilia, Beatriz, Iglesias, Eva, Alcaín, Guillermo, Pérez Martínez, Isabel, Rolle, Valeria, Castaño García, Andrés, Gisbert, Javier P., Domènech, Eugeni, The ENEIDA Registry From GETECCU |
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| Přispěvatelé: | [Riestra S] Gastroenterology Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain. [Taxonera C] Gastroenterology Department, Hospital Clínico Universitario San Carlos, Instituto de Investigación del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Zabana Y] Gastroenterology Department, Hospital Universitari Mútua Terrassa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Terrassa, Spain. [Carpio D] Gastroenterology Department, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain. [Chaparro M] Gastroenterology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain. [Barrio J] Gastroenterology Department, Hospital Universitario Río Hortega, Valladolid, Spain. [Piqueras M] Servei de Gastroenterologia, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain, Consorci Sanitari de Terrassa |
| Rok vydání: | 2022 |
| Předmět: |
Tuberculin skin test
Tuberculosi infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones por Actinomycetales::micobacteriosis::tuberculosis::tuberculosis latente [ENFERMEDADES] latent tuberculosis infection Interferó tuberculin skin test General Medicine Interferon gamma release assays Inflammatory bowel diseases interferon gamma release assays Inflammatory bowel disease diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::pruebas inmunológicas::análisis de la liberación del interferón gamma [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Malalties inflamatòries intestinals enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal [ENFERMEDADES] inflammatory bowel disease Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Immunologic Tests::Interferon-gamma Release Tests [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Tuberculosis Latent tuberculosis infection Intestins - Inflamació Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases [DISEASES] Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Actinomycetales Infections::Mycobacterium Infections::Tuberculosis::Latent Tuberculosis [DISEASES] |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Journal of Clinical Medicine r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname r-FISABIO. Repositorio Institucional de Producción Científica Journal of Clinical Medicine; Volume 11; Issue 13; Pages: 3915 Journal of clinical medicine r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe Scientia r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| ISSN: | 2077-0383 |
| Popis: | Inflammatory bowel disease; Interferon gamma release assays; Latent tuberculosis infection Enfermedad inflamatoria intestinal; Ensayos de liberación de interferón gamma; Infección tuberculosa latente Malaltia inflamatòria intestinal; Assajos d'alliberament gamma d'interferó; Infecció tuberculosa latent Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different LTBI screening strategies in patients with inflammatory bowel disease (IBD). Methods: Patients in the Spanish ENEIDA registry with IBD screened for LTBI between January 2003 and January 2018 were included. The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-ץ-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed. Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18−20%) had LTBI. Immunomodulator (IMM) treatment at screening decreased the probability of detecting LTBI (20% vs. 17%, p = 0.001). Regarding screening strategies, LTBI was more frequently diagnosed by dual screening than by a single screening strategy (IGRA, OR 0.60; 95% CI 0.50−0.73, p < 0.001; TST, OR 0.76; 95% CI 0.66−0.88, p < 0.001). Two-step TST increased the diagnostic yield of a single TST by 24%. More cases of LTBI were diagnosed by early screening than by routine screening before starting anti-TNF agents (21% [95% CI 20−22%] vs. 14% [95% CI 13−16%], p < 0.001). The highest diagnostic performance for LTBI (29%) was obtained by combining early and TST/IGRA dual screening strategies in patients without IMM. Conclusions: Both early screening and TST/IGRA dual screening strategies significantly increased diagnostic performance for LTBI in patients with IBD, with optimal performance achieved when they are used together in the absence of IMM. |
| Databáze: | OpenAIRE |
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