Histopathologic and Immunocytochemical Studies of Distemper in Harbor Porpoises
| Autor: | S. Kennedy, J. A. Smyth, S. J. McCullough, P. F. Cush, M. McAliskey, Bertus K. Rima |
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| Rok vydání: | 1991 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Necrosis 040301 veterinary sciences Dolphins Urinary Bladder Bronchi Spleen Phocoena Epithelium Immunoenzyme Techniques 0403 veterinary science 03 medical and health sciences Multinucleate Morbillivirus medicine Animals Distemper Antigens Viral Lung Cerebral Cortex Neurons General Veterinary biology 04 agricultural and veterinary sciences respiratory system biology.organism_classification medicine.disease Immunohistochemistry respiratory tract diseases Cetacean morbillivirus 030104 developmental biology medicine.anatomical_structure Gastric Mucosa Paramyxoviridae Lymph Nodes medicine.symptom Infiltration (medical) |
| Zdroj: | Veterinary Pathology. 28:1-7 |
| ISSN: | 1544-2217 0300-9858 |
| Popis: | During 1988 thousands of harbor seals ( Phoca vitulina) died in European seas as a result of morbillivirus infection. Six harbor porpoises ( Phocoena phocoena) found stranded on the coast of Northern Ireland in late 1988 were submitted to our laboratory for necropsy. Pneumonia was the main necropsy finding in three of these animals. Microscopic lung lesions characterized by necrosis of bronchial and bronchiolar epithelium and infiltration of alveoli with leukocytes, lymphoid cells, macrophages, and multinucleate syncytia were seen in all six porpoises. Cytoplasmic and nuclear acidophilic inclusions characteristic of morbillivirus infection were common in bronchial and bronchiolar epithelial cells and in alveolar macrophages and syncytia. Brain alterations included degeneration and necrosis of neurons, microglial infiltration, and perivascular cuffing. There were cytoplasmic and nuclear acidophilic inclusions in many neurons. Immunoperoxidase staining of morbillivirus antigen was seen in many tissues including lung, brain, spleen, and urinary bladder. Alterations in our porpoises were similar to those seen in distemper in seals and many species of terrestrial mammals. Systemic viral disease has not previously been documented in Cetacea. |
| Databáze: | OpenAIRE |
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