Rotavirus hospitalizations among children5 years of age-Tajikistan, 2013-2014
| Autor: | Anvar B. Nazurdinov, Eyal Leshem, Zafarjon A. Azizov, Farida Tishkova, Sohibnazar M. Turkov, Danni S. Daniels |
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| Rok vydání: | 2017 |
| Předmět: |
Diarrhea
Male Rotavirus Tajikistan Pediatrics medicine.medical_specialty Genotype viruses Enzyme-Linked Immunosorbent Assay 030204 cardiovascular system & hematology medicine.disease_cause Rotavirus disease Rotavirus Infections 03 medical and health sciences Feces fluids and secretions 0302 clinical medicine medicine Humans 030212 general & internal medicine General Veterinary General Immunology and Microbiology business.industry Immunization Programs Public Health Environmental and Occupational Health Infant Newborn Rotavirus Vaccines virus diseases Infant Acute gastroenteritis Rotavirus vaccine Vaccine introduction Gastroenteritis Hospitalization Infectious Diseases Child Preschool Acute Disease Molecular Medicine Immunization program Female Seasons business Sentinel Surveillance |
| Zdroj: | Vaccine. 36(51) |
| ISSN: | 1873-2518 |
| Popis: | In January 2015, Tajikistan introduced the monovalent rotavirus vaccine into the national immunization program. Our objective was to estimate pre-vaccine burden of rotavirus-associated hospitalizations in children5 years of age in Tajikistan.During January 2013-December 2014, active surveillance for acute gastroenteritis (AGE)-associated hospitalizations in children5 years of age was conducted by sentinel surveillance site staff. Patients' demographic and clinical data were summarized and a stool sample was collected. An Enzyme Linked Immunosorbent Assay was used for diagnosis of rotavirus infection and subset of the specimens was sent for polymerase chain reaction (PCR) genotyping.Of 2860 eligible children enrolled and tested, 1207 (42%) were positive for rotavirus. An increase in the number and proportion of rotavirus cases attributed to rotavirus season, with positivity rates40%, was annually observed during June-September. The median age of rotavirus patients was 9 months and 939/1207 (78%) rotavirus patients were aged 6-23 months. Most (1097/1203; 91%) rotavirus patients were treated with intravenous fluids. G1P[8] was the predominant genotype during both years of surveillance, accounting for 133/222 (60%) of genotyped cases.Rotavirus is a major cause of hospitalization due to severe AGE in children5 years of age in Tajikistan, accounting for40% of cases. Continued, enhanced rotavirus surveillance may allow documentation of changes in rotavirus disease burden following vaccine introduction and assessment of vaccine effectiveness. |
| Databáze: | OpenAIRE |
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