Responses of essential fatty acid-deficient rats to fasting-refeeding and partial hepatectomy
| Autor: | M. A. Ojakian, M. A. Williams, K. T. Tamai, N. Waldeck, I. Hincenbergs |
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| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Phospholipid Dehydrogenase Arachidonic Acids Partial hepatectomy Biology Glucosephosphate Dehydrogenase General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Membrane Lipids Essential fatty acid Internal medicine medicine Animals Hepatectomy Phospholipids chemistry.chemical_classification Fatty Acids Essential Body Weight Fatty acid Fasting Organ Size Rats Fasting refeeding Endocrinology chemistry Liver Essential fatty acid deficient Fatty Acids Unsaturated Fatty Acid Synthases |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 155(4) |
| ISSN: | 0037-9727 |
| Popis: | SummaryEssential fatty acid-deficient rats were subjected to fasting-refeeding or partial hepatectomy to stimulate liver phos-pholipid and membrane formation under conditions of limited essential fatty acid (EFA) supply. Refeeding after fasting decreased the proportion of arachidonate in liver phospholipid fatty acids only slightly, i.e., from 6.8% in nonfasted rats to 5.3% after 3 or 7 days of refeeding, whereas ei-cosatrienoate decreased from 19.8% in nonfasted rats to 13.0% after 3 days of refeeding, with a return to nonfasted levels after 7 days. Activities of liver glucose-6-phosphate dehydrogenase and fatty acid synthetase in fasted-refed EFA-deficient rats did not differ significantly from values in deficient rats fed ad libitum. Considerable increase in liver weight (ca. 3-8 g or at least 50% of the estimated preoperative weight) occurred after partial hepatectomy of EFA-deficient rats. The proportion of arachidon-ate in phospholipid fatty acids was slightly lower after hepatectomy than before.The... |
| Databáze: | OpenAIRE |
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