Prognostic and Clinicopathological Value of Ki-67 in Melanoma: A Meta-Analysis
| Autor: | Liangfang Shen, Lin Shen, Qixin Liu, Ziheng Peng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Cochrane Library Internal medicine melanoma clinicopathology Overall survival Medicine RC254-282 biology business.industry Melanoma Hazard ratio Neoplasms. Tumors. Oncology. Including cancer and carcinogens Odds ratio medicine.disease Confidence interval meta-analysis Ki-67 Meta-analysis biology.protein Systematic Review prognosis business |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 11 (2021) |
| ISSN: | 2234-943X |
| Popis: | BackgroundThe prognostic and clinicopathological value of Ki-67 in melanoma is controversial. The purpose of this meta-analysis was to determine the prognostic role of Ki-67 in melanoma patients.Materials and MethodsThe PubMed, Cochrane Library, Web of Science, and Embase databases were searched systematically up to April 9, 2021. We calculated the pooled hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between Ki-67 overexpression and survival outcomes. We also calculated the combined odds ratios (ORs) and 95% CIs to determine the relationship between Ki-67 expression levels and clinicopathologic parameters. All data were statistically analyzed by Stata 11.0.ResultsA total of 10 studies involving 929 patients were included in our meta-analysis. The pooled HR showed that Ki-67 overexpression was connected with poor overall survival rates (HR=2.92, 95% CI=2.17-3.91, pConclusionKi-67 is a useful poor prognostic indicator for melanoma patients. |
| Databáze: | OpenAIRE |
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