Emerging Roles for the Lysosome in Lipid Metabolism
| Autor: | Roberto Zoncu, Ashley M. Thelen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
1.1 Normal biological development and functioning membrane contact sites mTORC1 Mechanistic Target of Rapamycin Complex 1 Models Biological Medical and Health Sciences Article 03 medical and health sciences Models Underpinning research Lipid droplet Lysosome Lipid biosynthesis medicine Animals Humans Homeostasis 2.1 Biological and endogenous factors Aetiology Mechanistic target of rapamycin Lipid Transport Nutrition biology cholesterol Biological Transport Lipid metabolism Cell Biology Biological Sciences Biological Lipid Metabolism Lipids Cell biology Cholesterol 030104 developmental biology medicine.anatomical_structure Biochemistry lysosome biology.protein lipids (amino acids peptides and proteins) Generic health relevance Lysosomes Biogenesis Developmental Biology |
| Zdroj: | Trends in cell biology, vol 27, iss 11 |
| ISSN: | 0962-8924 |
| DOI: | 10.1016/j.tcb.2017.07.006 |
| Popis: | Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of cells and organisms. Cells rely on a sophisticated but poorly understood network of vesicular and non-vesicular transport mechanisms to ensure efficient delivery of lipids to target organelles. The lysosome stands at the crossroads of this network due to its ability to process and sort exogenous and endogenous lipids. The lipid sorting function of the lysosome is intimately connected to its recently discovered role as a metabolic command-and-control center, which relays multiple nutrient cues to the master growth regulator, mechanistic Target of Rapamycin Complex 1 (mTORC1) kinase. In turn, mTORC1 potently drives anabolic processes, including de novo lipid synthesis, while inhibiting lipid catabolism. Here we describe the dual role of the lysosome in lipid transport and biogenesis, and we discuss how integration of these two processes may play important roles both in normal physiology and in disease. |
| Databáze: | OpenAIRE |
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