Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype

Autor: Landburg, P. P., Teerlink, T., Biemond, B. J., Brandjes, D. P. M., Muskiet, F. A. J., Duits, A. J., Schnog, J. B., Grp, C. U. R. A. M. A. Study
Přispěvatelé: Laboratory Medicine, ICaR - Ischemia and repair, Faculteit Medische Wetenschappen/UMCG, Lifestyle Medicine (LM), Other departments, AII - Amsterdam institute for Infection and Immunity, CCA -Cancer Center Amsterdam, Clinical Haematology
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Male
Asymmetric dimethylarginine
Priapism
PULMONARY-HYPERTENSION
chemistry.chemical_compound
Cholelithiasis
hemic and lymphatic diseases
RISK
Leg Ulcer
Osteonecrosis
DEATH
ASSOCIATION
Hematology
Middle Aged
Brain natriuretic peptide
Hemolysis
Phenotype
BRAIN NATRIURETIC PEPTIDE
ARGININE METABOLISM
Molecular Medicine
Female
Retinopathy
Adult
medicine.medical_specialty
congenital
hereditary
and neonatal diseases and abnormalities
OXIDE SYNTHASE INHIBITOR
Anemia
Hypertension
Pulmonary
Anemia
Sickle Cell
Arginine
Nitric Oxide
Sickle Cell Trait
Young Adult
Retinal Diseases
Internal medicine
medicine
Albuminuria
Humans
ANEMIA
Beta (finance)
Molecular Biology
business.industry
Sickle cell disease
MORTALITY
beta-Thalassemia
Cell Biology
medicine.disease
Pulmonary hypertension
Endocrinology
chemistry
business
RESISTANCE
Zdroj: Blood Cells Molecules and Diseases, 44(4), 229-232. Academic Press Inc.
Landburg, P P, Teerlink, T, Biemond, B J, Brandjes, D P M, Muskiet, F A J, Duits, A J & Schnog, J B 2010, ' Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype ', Blood Cells Molecules and Diseases, vol. 44, no. 4, pp. 229-232 . https://doi.org/10.1016/j.bcmd.2010.02.005
Blood cells molecules and diseases, 44(4), 229-232
Blood cells, molecules & diseases, 44(4), 229-232. Academic Press Inc.
ISSN: 1079-9796
DOI: 10.1016/j.bcmd.2010.02.005
Popis: Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in sickle cell disease (SCD). We studied the relationship of ADMA to other SCD-related complications. Plasma ADMA and associated parameters were determined in 52 HbSS/HbS beta(0)-thalassemia and 24 HbSC/HbS beta(+)-thalassemia patients. As expected ADMA levels were higher in HbSS/HbS beta(0)-thalassemia patients with PHT (p = 0.018), but also in those with other hemolysis-associated complications such as leg ulcers (p = 0.012), cholelithiasis (p = 0.008) and priapism (p = 0.02) compared with counterparts without these complications. ADMA levels did not differ between patients with and without other disease related complications such as retinopathy and avascular osteonecrosis. Higher ADMA concentrations therefore seem to be associated to the hemolytic phenotype of SCD. (c) 2010 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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