Prognostic Factors Influencing Infection-related Mortality in Patients with Acute Leukemia in Korea
Autor: | Woo-Sung Min, Dong-Gun Lee, Su-Mi Choi, Jin-Hong Yoo, Jung-Hyun Choi, Chun-Choo Kim, Wan-Shik Shin |
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Jazyk: | angličtina |
Rok vydání: | 2009 |
Předmět: |
Adult
Male medicine.medical_specialty Neutropenia Adolescent medicine.medical_treatment Hematopoietic stem cell transplantation Sepsis Internal medicine Cause of Death medicine Humans Intensive care medicine Survival rate Prognosis Neutropenia Cause of death Aged Retrospective Studies Acute leukemia Leukemia Korea business.industry Retrospective cohort study General Medicine Bacterial Infections Pneumonia Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Prognosis Fungal Infection Survival Rate Leukemia Myeloid Acute Mycoses Multivariate Analysis Original Article Female Morbidity business Infection |
Zdroj: | Journal of Korean Medical Science |
ISSN: | 1598-6357 1011-8934 |
Popis: | We retrospectively reviewed the medical records of 284 patients with neutropenic fever following chemotherapy for acute leukemia at the Catholic Hematopoietic Stem Cell Transplantation Center from January 1998 to December 1999, to identify prognostic factors for infection-related mortality. Twenty-eight patients died of infections. There was no difference in median age, gender ratio, or underlying disease between the dying and surviving groups. Bacteria were the main pathogens following chemotherapy, and Gram positive organisms predominated in the dying group. Pneumonia and sepsis were the main causes of death. There were 72 cases of invasive fungal infection and their mortality was 27.8%. Invasive fungal infection and previous history of fungal infection were independent prognostic factors for outcome. Recovery from neutropenia was the significant protective factor for mortality. In conclusion, the prognostic factors identified in this study could be useful for deciding on more intensive treatment for those patients at greater risk of death. To our knowledge, this is the first Korean study delineating prognostic factors in acute leukemic patients with infectious complications. |
Databáze: | OpenAIRE |
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